This paper analyzes feelings of insecurity and fear amongst the population of Siberian regions in the face of various perceived dangers, based on research conducted in the Krasnoiarsk and Altai Territories, Novosibirsk and Omsk Regions, and the Republics of Khakassiia and Buriatiia, in the context of the general Russian situation. Quantitative methods—frequency, correlation, and factor analysis on survey data obtained from formalized face-to-face interviews—are used to gain an understanding of what factors respondents feel are “ugrozhaiushchie zhiznedeiatel’nosti” (activities threatening to social life). Siberians feel especially vulnerable to gender- and age-related discrimination, as well as governmental abuse of power and the threats inherent in economic development: chronic poverty, environmental threats, officials’ arbitrariness, and crime and law enforcement authorities themselves. They also feel threatened by the presence of migrant groups and social minorities. However, an internal locus of control reduces their fears of threats to social life activities.