Здоровье всегда являлось весомым капиталом человека, а грамотное распоряжением им всегда приносило ощутимые инвестиции. В современном мире с его темпами, задачами и вызовами у большинства людей все меньше времени остается на сохранение, поддержание и тем более укрепление здоровья. Но на возникающий запрос, формируется решение, продиктованное самим обществом, а именно, его цифровым отражением. Оцифровка общественной и ...
Added: May 15, 2023
Баранова Е. Е., Брызгалина Е. В., Введенская Е. В. et al., ИНИОН РАН, 2021
В монографии рассматриваются этико-правовые и социально-психологические проблемы развития геномной медицины. Особое внимание уделяется биоэтическим вопросам развития биобанкинга, генетического тестирования, медико-генетического консультирования, а также проблемам социогуманитарного сопровождения развития генетических технологий в нашей стране. Для всех, кто заинтересован в понимании этических, правовых и социальных контекстов развития геномной медицины. ...
Added: January 13, 2022
Манухов И. В., Springer Nature. Springer Science+Business Media, LLC, Humana Press., 2019
Cancer cells require exogenous methionine for survival and therefore methionine restriction is a promising
avenue for treatment. The basis for methionine dependence in cancer cells is still not entirely clear. While
the lack of the methionine salvage enzyme methylthioadenosine phosphorylase (MTAP) is associated with
methionine auxotrophy in cancer cells, there are other causes for tumors to require exogenous ...
Added: March 3, 2020
Белинская Е. П., Бондарев Д. В., Бочавер К. А. et al., М. : Издательство «Перо», ИММ-Пресс, 2018
В монографии представлен новый, междисциплинарный подход в психологии здоровья, позволяющий врачам, психологам, дизайнерам, архитекторам, педагогам, специалистам в области управления персоналом изучить механизмы поддержания и укрепления здоровья, повышения благополучия и продуктивности человека в современном обществе. Здоровье рассматривается с позиций организации труда и обучения, управления стрессом, пищевого поведения, физической активности, устройства жизненной среды, семейной структуры
и общественных отношений. ...
Added: July 3, 2018
Semyachkina-Glushkovskaya O., Fedosov I., Ageev V. et al., Biomedical Optics Express 2024 Vol. 15 No. 1 P. 44-58
In this study on healthy male mice using confocal imaging of dye spreading in the brain and its further accumulation in the peripheral lymphatics, we demonstrate stronger effects of photobiomodulation (PBM) on the brain’s drainage system in sleeping vs. awake animals. Using the Pavlovian instrumental transfer probe and the 2-objects-location test, we found that the ...
Added: March 12, 2024
Demichev V., Tober-Lau P., Nazarenko T. et al., PLOS digital health 2022 Article e0000007
Global healthcare systems are challenged by the COVID-19 pandemic. There is a need to optimize allocation of treatment and resources in intensive care, as clinically established risk assessments such as SOFA and APACHE II scores show only limited performance for predicting the survival of severely ill COVID-19 patients. Additional tools are also needed to monitor ...
Added: March 12, 2024
Gao H., Liu L., Zaikin A. et al., Biochimica et Biophysica Acta - Biomembranes 2023 Vol. 7 No. 1865 Article 184195
Numerous cellular processes are regulated by Ca2+ signals, and the endoplasmic reticulum (ER) membrane's inositol triphosphate receptor (IP3R) is critical for modulating intracellular Ca2+ dynamics. The IP3Rs are seen to be clustered in a variety of cell types. The combination of IP3Rs clustering and IP3Rs-mediated Ca2+-induced Ca2+ release results in the hierarchical organization of the Ca2+ signals, which challenges the numerical ...
Added: February 28, 2024
Кутлубаев М. А., Шагиева Д. Р., Каримова Г. И. et al., Журнал высшей нервной деятельности им. И.П. Павлова 2023 Т. 73 № 5 С. 651-665
Pupillometry is a method allowing quantitative assessment of the pupil diameter. The size of the pupil is regulated by the structures of autonomic nervous system (nuclei of the oculomotor nerve, ciliospinal center) and related to the ambient lighting. However, overlying structures of the brain, in particular cortex, via locus coeruleus, upper colliculi of quadrigeminal bodies ...
Added: February 9, 2024
Popkov A., Dubnov Y. A., Popkov Y., Информационные технологии и вычислительные системы 2022 № 3 С. 67-78
The work is devoted to application of the theory of Randomized Machine Learning to forecasting of the COVID-19 pandemic based on SIR epidemiological model. We propose two modelling variants, the first is based on estimation of SIR model using real case data, the second is based on the idea of modelling transmission coefficient and its prediction. Comparative study ...
Added: February 5, 2024
А. Ю. Попков, Ю. А. Дубнов, Ю. С. Попков, Информатика и автоматизация (Труды СПИИРАН) 2022 Т. 4 № 21 С. 659-677
We propose an approach to estimation of the parameters of non-linear dynamic models using the concept of Randomized Machine Learning (RML), based on the transition from deterministic models to random ones (with random parameters), followed by estimation of the probability distributions of parameters and noises on real data. The main feature of this method is ...
Added: February 5, 2024
Shalileh S., Koptseva A., Шишковская Т. И. et al., Доклады Российской академии наук. Математика, информатика, процессы управления (ранее - Доклады Академии Наук. Математика) 2023 Т. 514 № 2 С. 242-249
This paper represents our research to (i) propose an artificial intelligence, AI-based solution to identify depression and (ii) investigate our psychiatric knowledge. Concerning the first objective, we collected and annotated a new audio data set, and scrutinized the performance of eight regression approaches. Our studies showed that k-nearest neighbor and random forest form the group ...
Added: February 2, 2024
Ilya E. Nifant’ev, Tavtorkin A., Maria P. Ryndyk et al., ACS Applied Bio Materials 2023 Vol. 6 No. 11 P. 5067-5077
Carbonated hydroxyapatites (CAp) are very close to natural bone apatite in chemical composition and are regarded as a prospective bone mineral substitute for bone surgery and orthopedics. However, until now, the
studies and applications of CAp were limited because of the amorphous nature of the synthetic CAp. In the present work, microsized highly crystalline carbonated apatites ...
Added: December 13, 2023
Kuzin A., Chernyshev V., Kovalyuk V. et al., Applied Physics Letters 2023 Vol. 123 P. 1-5
Today, the search for disease biomarkers and techniques for their detection is one of the most important focuses in modern healthcare. Extracellular vesicles (EVs) are known to be related to the pathogenesis of various illnesses, such as cancer, neurodegenerative disease, and cardiovascular disease. Specific EV detection and potential control of their amount in biological fluids ...
Added: November 8, 2023
Gracheva M., Shalileh S., Клиническая и специальная психология 2023 Т. 12 № 3 С. 1-29
The review considers methods of dyslexia diagnostics based on eye movement data and implemented on the basis of artificial intelligence. A number of studies have shown that eye movements in people with dyslexia may differ from those of people with normal reading abilities. Since 2015, studies have begun to appear in which the eye movements ...
Added: November 5, 2023
Gromov V., Zvorykina E., Beschastnov Y. et al., Working papers by Cornell University. Series math "arxiv.org" 2023 Article 14399
The paper explores mathematical methods that differentiate regular and chaotic time series, specifically for identifying pathological fistulas. It proposes a noise-resistant method for classifying responding rows of normally and pathologically functioning fistulas. This approach is grounded in the hypothesis that laminar blood flow signifies normal function, while turbulent flow indicates pathology. The study explores two ...
Added: September 27, 2023
Functional connectivity is crucial for cognitive processes in the healthy brain and serves as a marker for a range of neuropathological conditions. Non-invasive exploration of functional coupling using temporally resolved techniques such as MEG allows for a unique opportunity of exploring this fundamental brain mechanism.
The indirect nature of MEG measurements complicates the estimation of functional coupling due to the volume ...
Added: September 24, 2023
Margarita R. Chetyrkina, Cvjetinovic J., Fedorov F. et al., ACS Photonics 2022 Vol. 9 No. 10 P. 3429-3439
Optoacoustic (photoacoustic) imaging has gained tremendous attention in research and in clinical practice as a point-of-care system for noninvasive, fast, and safe tests. The first optoacoustic (OA) tomograph has recently passed the Food and Drug Administration (FDA) approval stage for clinical applications aimed at early breast cancer diagnostics. Furthermore, a broad application of OA imaging ...
Added: September 11, 2023
Khabibullin V., Margarita R. Chetyrkina, Obydennyy S. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 5 Article 4480
Nanoplatforms applied for the loading of anticancer drugs is a cutting-edge approach for drug delivery to tumors and reduction of toxic effects on healthy cells. In this study, we describe the synthesis and compare the sorption properties of four types of potential doxorubicin-carriers, in which iron oxide nanoparticles (IONs) are functionalized with cationic (polyethylenimine, PEI), ...
Added: September 5, 2023
Koshev N., Kapralov P., Evstigneeva S. et al., IEEE Transactions on Biomedical Engineering 2024 Vol. 71 No. 1 P. 122-129
In the current article, we present a new kind of magnetometer for quantitative detection of magnetic objects (magnetic nano- and submicron particles) in biological fluids and tissues. The sensor is based on yttrium-iron garnet film with optical signal registration system. Inheriting the working principle of a fluxgate magnetometers, the sensor works at a room-temperature, its ...
Added: August 29, 2023
Hein T., Gong Z., Ivanova M. et al., Communications Biology 2023 Vol. 6
Anxiety has been linked to altered belief formation and uncertainty estimation, impacting learning. Identifying the neural processes underlying these changes is important for understanding brain pathology. Here, we show that oscillatory activity in the medial prefrontal, anterior cingulate and orbitofrontal cortex (mPFC, ACC, OFC) explains anxiety-related learning alterations. In a magnetoencephalography experiment, two groups of ...
Added: June 7, 2023
Proskurnina E., Liaukovich K., Bychkovskaya L. et al., Metabolites 2023 Vol. 13 No. 1 Article 73
Abstract: Generalized anxiety disorder (GAD) is a prevalent disorder. The search for biomarkers may contribute to new knowledge about molecular pathogenesis and treatment. Since oxidative stress and micronutrient imbalance play a key role in the development of mental disorders, we aimed to study salivary antioxidant capacity and magnesium in patients with GAD in an anxiety ...
Added: May 15, 2023
Vorontsova D. V., Zubov A. I., Isaeva M. V. et al., Computer Research and Modeling 2023
Using data analysis and indirect application of neural networks in our work, we identified patterns of brain electrical activity that characterize COVID−19. We were interested in frequency, temporal, and spatial domain patterns of electrical activity in people who have undergone COVID−19.
We found a predominance of α−rhythm patterns in the left hemisphere in healthy people compared ...
Added: April 26, 2023
Menshikov I., Orlov K., Berestov V. et al., Proceedings of the IEEE 2023
in print ...
Added: April 26, 2023
Menshikov I., Orlov K., Berestov V. et al., Proceedings of the IEEE 2023 Article 42
in print ...
Added: April 26, 2023
Razorenova A., Yavich N., Malovichko M. et al., / Cold Spring Harbor Laboratory. Series 005140 "Biorxiv". 2020.
Electroencephalography (EEG) is a well-established non-invasive technique to measure the brain activity, albeit with a limited spatial resolution. Variations in electric conductivity between different tissues distort the electric fields generated by cortical sources, resulting in smeared potential measurements on the scalp. One needs to solve an ill-posed inverse problem to recover the original neural activity. ...
Added: November 10, 2020