This book examines how Russia, the world’s most complicated country, is governed. As it resumes its place at the centre of global affairs, the book explores Russia’s overarching strategies, and how it organizes itself (or not) in policy areas ranging from foreign policy and national security to health care, education, immigration, science, sport, agriculture, the environment and criminal justice. The book also discusses the structures and institutions on which Russia relies in order to deliver its goals in these areas of national life, as well as what’s to be done, in policy terms, to improve the country’s performance in its first post-Soviet century. Edited by Irvin Studin, the book includes contributions from a tremendous list of Russia’s leading thinkers and specialists, including Alexei Kudrin, Vladimir Mau, Alexander Auzan, Simon Kordonsky, Fyodor Lukyanov, Natalia Zubarevich and Andrey Melville.
The development and use of Genetically modified organisms (GMOs) has been a contentios subject for the last three decades. while there has been a number of social science analysis of the issues, this is the first book to assess the role of non-governmental organizations (NGOs) in the debate at such wide geographic scale. The various posiotions, for and against GMOs, particularly with regards to trangenic crops, articulated by NGOs in the debate are dissected, classified and juxtaposed to corresponding campaigns. these are discussed in the context of paradigms, including nature fundamentalism and the organic movement, post-colonialism, food sovereignty, anti-globalism, sustainability and feminism. This book also analyses how NGOs interprete the debate and the persuasive communication tactics.
The Paris Climate Agreement established a new target of combating global warming "well below 2 degrees Celsius". This goal will lead to the transformation and deep decarbonization of world economy aiming at nearly zero carbon emissions soon after 2050. The Northeastern Asian countries (responsible for 40% of global CO2 emissions) have all rechnological, resource and ivnestment potential for decarbonization both domestically and internationally, and can show leadership in this efforts on global scale.
The book provides the first in-depth, multidisciplinary study of reurbanization in Russia's Arctic regions, with a specific focus on new mobility patterns, and the resulting birth of new urban Arctic identities in which newcomers and labor migrants form a rising part. It is an invaluable reference for all those interested in current trends in circumpolar regions, showing how the Arctic is becoming more diverse culturally, but also more integrated into globalized trends in terms of economic development, urban sustainability, and migration.
The piblication provides the key lessons learnt from DDPP project experience on designing long-term pathways of low carbon development for 16 world largest economies. The Paris Climate Agreement requires countries to build their concrete vision of the national low-emission transition, consistent with global climate goals that would widely shared by domestic stakeholders and explicitly articulated with domestic socio-economic priorities. We analyze the experience of USA, France, Germany, Russia, China, India, Indonesia, Japan, UK, Mexico, Canada, Italy, Brazil in projecting the deep decarbonization scenarios for their economies by 2050.
The book presents a brief summary of the scientific research on deep decarbonization of 16 largest economies by 2050.
This report examines the changes happening in Russia ever since the issue of global warming was introduced on the global agenda. Only today, after the planet has experienced a variety of catastrophic natural disasters, have world leaders and decision makers grown more aware of the urgency of the problem. In Russia, where climate changes have been more significant than globally on average, the government has increased its objectives in reducing greenhouse gas emissions and put forward a number of initiatives and green policy measures to achieve more sustainability in the long term. Russia’s target for greenhouse gas emissions in 2030 is set at 70-75 percent of the base level of 1990, according to the new action plan adopted by the Kremlin. Other states also recognize the problem but their positions differ in the way the issue should be solved. India, China, the U.S. and Brazil, all of which are important players analyzed in the report, find it hard to reach common ground in reaching a globally binding agreement. Whether this will be done ultimately depends on the outcome of the Paris climate change conference. The report also considers the state of the Russian climate change movement from the experience of NGO activities in Russia, provides an overview of the development of the Russian green energy sector with specific success stories and analyzes the prospects of renewable energy development in different regions of the country.
This supplementary material contains case studies presenting specific aspects of the DDPP country pathways. They illustrate and complement the cross-cutting analysis included in the 2015 DDPP synthesis report
The Deep Decarbonization Pathways Project (DDPP) is a collaborative global research initiative seeking to understand how individual countries can transition, on a technological, socio-economic and policy “pathway”, to a low-carbon economy consistent with the internationally agreed goal of limiting anthropogenic warming to less than 2 degrees Celsius (2°C). Achieving this goal requires that the world cut global net emissions of greenhouse gases (GHG) so that they approach zero between 2050 and 2075, consistent with the Intergovernmental Panel on Climate Change (IPCC)1 2014 findings that to ensure a better-than-even chance of remaining below a 2°C temperature rise, global annual emissions will need to be reduced 42%–57% by 2050 (relative to 2010), and 73%–107% by 2100. This will entail, more than any other factor, the profound transformation of energy systems through steeply reducing carbon intensity in all sectors of the economy. We call this transition “deep decarbonization” and our products, Deep Decarbonization Pathways (DDPs).
The present volume is the fourth issue of the Yearbook series entitled ‘Evolution’. The title of the present volume is ‘From Big Bang to Nanorobots’. In this way we demonstrate that all phases of evolution and Big History are covered in the articles of the present Yearbook. Several articles also present the forecasts about future development.
The main objective of our Yearbook as well as of the previous issues is the creation of a unified interdisciplinary field of research in which the scientists specializing in different disciplines could work within the framework of unified or similar paradigms, using the common terminology and searching for common rules, tendencies and regularities. At the same time for the formation of such an integrated field one should use all available opportunities: theories, laws and methods. In the present volume, a number of such approaches are used.
The volume consists of four sections: Universal Evolutionary Principles; Biosocial Evolution, Ecological Aspects, and Consciousness; Projects for the Future; In Memoriam.
This Yearbook will be useful both for those who study interdisciplinary macroproblems and for specialists working in focused directions, as well as for those who are interested in evolutionary issues of Cosmology, Biology, History, Anthropology, Economics and other areas of study. More than that, this edition will challenge and excite your vision of your own life and the new discoveries going on around us!
The Deep Decarbonization Pathways Project (DDPP) is a collaborative initiative to understand and show how individual countries can transition to a low-carbon economy and how the world can meet the internationally agreed target of limiting the increase in global mean surface temperature to less than 2 degrees Celsius (°C). Achieving the 2°C limit will require that global net emissions of greenhouse gases (GHG) approach zero by the second half of the century. This will require a profound transformation of energy systems by mid-century through steep declines in carbon intensity in all sectors of the economy, a transition we call “deep decarbonization.” Successfully transitioning to a low-carbon economy will require unprecedented global cooperation, including a global cooperative effort to accelerate the development and diffusion of some key low carbon technologies.
This collection is a special issue of Russian Sociological Review dedicated to the concept of border. The concept itself seems to draw attention in many disciplines. As spatial phenomena, borders are always drawn in spaces, while social scientists, philosophers and other academics often have different meanings of space. Recent reconsiderations of space in terms of networks, flows and events, bring even more complexity to the concept. The current volume contributes to both theoretical and empirical studies of borders on various levels. Contributions look at the relevant phenomena from contemporary or historical perspectives, study narratives about borders, reconstructions of the empirical configurations of borders and other objects (such as bodies), exploring how borders emerge and reshape existing spaces, etc. Overall, the issue contributes to the emerging interdisciplinary field of border studies and encourages cross-disciplinary dialogue.
Work-book «The current state of the Russian oil and gas industry» is offered for publication as a training aid for students qualified at the direction 131000 “Oil and gas engineering”. We have described the geology of hydrocarbons, in particular - the geology of heavy oil, unconventional resources of energy, etc. In this workbook there are also methods for the development of deposits of heavy oil and produce shale oil. Special attention was given to unconventional sources of hydrocarbons, exactly, gas hydrates and clayey shale. Novelty of work-book is presentation of oil and gas terminology to students from China. This work-book is published for the first time and will be very useful for self-study students of oil and gas disciplines, as well as oil and gas terms in Russian, English and Chinese. The manuscript is classified as «Approved by UMO on Higher Education in the field of applied geology as a work book for students enrolled in the direction 131000 “Oil and Gas Engineering”».
Climate change is already having a negative impact on agricultural production in Russia, especially grain production, since this sector is perhaps the most dependent on weather and climate factors. This report presents an economic evaluation of the impact of climate change on crop production at the national level and a long-term economic evaluation of the losses, profits, and risks for agriculture throughout Russia. It analyses the situation in the two the major agricultural regions, where the negative effects of climate change are especially pronounced, and examines the prospects for adapting Russia’s agriculture to climate change
The study includes a variety of topics, from a review of the political, legal and institutional frameworks for the development of a “green economy” in Russia, to concrete practices of separate waste collection, the development of renewable energy sources and aspects of environmental education. We tried to look at the process of sustainable development in Russia from diff erent perspectives, including the political and economic background, the legal situation, existing practices of sustainable development and how environmental information circulated, including journalism and education on sustainable development. The result is a broad study, which includes a collection of articles written by both theorists and practitioners of sustainable development in Russia.
Human reasoning uses to distinguish things that do change and things do not. The latter are commonly expressed in the reasoning as objects, which may represent classes or instances, and classes being further divided into concept types and relation types. These became the main issue of knowledge engineering and have been well tractable by computer. The former kind of things, meanwhile, inevitably evokes consideration not only of a ``thing-that-changes'' but also of ``change-of-a-thing'' and thus claims that the change itself be another entity that needs to be comprehended and handled. This special entity, being treated from different perspectives as event, (changeable) state, transformation, process, scenario and the like, remains a controversial philosophical, linguistic and scientific entity and has gained notably less systematic attention by knowledge engineers than non-changing things. In particular, there is no clarity in how to express the change in knowledge engineering -– as some specific concept or relation type, as a statement, or proposition, in which subject is related to predicate(s), or in another way. There seems to be an agreement among the scientists that time has to be related, explicitly or implicitly, to everything we regard as change -– but the way it should be related, and whether this should be exactly the time or some generic property or condition, is also an issue of debate. To bring together the researchers who study representation of change in knowledge engineering both in fundamental and applied aspects, a workshop on Modeling States, Events, Processes and Scenarios (MSEPS 2013) was run on 12 January, 2013, in the framework of the 20th International Conference on Conceptual Structures (ICCS 2013) in Mumbai, India. Seven submissions were selected for presentation that cover major approaches to representation of the change and address such diverse domains of knowledge as biology, geology, oceanography, physics, chemistry and also some multidisciplinary contexts. Concept maps of biological and other transformations were presented by Meena Kharatmal and Nagarjuna Gadiradju. Their approach stems from conceptual graphs of Sowa and represents the vision of change as a particular type of concept or, likely, relation, defined by meaning rather than by formal properties. The work of Prima Gustiene and Remigijus Gustas follows a congenial approach but develops a different notation for representation of the change based on specified actor dependencies in application to business issues concerning privacy-related data. Nataly Zhukova, Oksana Smirnova and Dmitry Ignatov explore the structure of oceanographic data in concern of opportunity of their representation by event ontologies and conceptual graphs. Vladimir Anokhin and Biju Longhinos examine another Earth science, geotectonics, and demonstrate that its long-lasting methodological problems urge application of knowledge engineering methods, primarily engineering of knowledge about events and processes. They suggest a draft of application strategy of knowledge engineering in geotectonics and claim for a joint interdisciplinary effort in this direction. Doji Lokku and Anuradha Alladi introduce a concept of ``purposefulness'' for any human action and suggest a modeling approach based on it in the systems theory context. In this approach, intellectual means for reaching a purpose are regarded either as structure of a system, in which the purpose is achieved, or as a process that takes place in this system. These means are exposed to different concerns of knowledge, which may be either favorable or not to achieving the purpose. The resulting framework perhaps can be described in a conceptual-graph-related way but is also obviously interpretable as a statement-based pattern, more or less resembling the event bush (Pshenichny et al., 2009). This binds all the aforementioned works with the last two contributions, which represent an approach based on understanding of the change as a succession of events (including at least one event), the latter being expressed as a statement with one subject and finite number of predicates. The method of event bush that materializes this approach, previously applied mostly in the geosciences, is demonstrated here in application to physical modeling by Cyril Pshenichny, Roberto Carniel and Paolo Diviacco and to chemical and experimental issues, by Cyril Pshenichny. The reported results and their discussion form an agenda for future meetings, discussions and publications. This agenda includes, though is not limited to, - logical tools for processes modeling, - visual notations for dynamic knowledge representation, - graph languages and graph semantics, - semantic science applications, - event-driven reasoning, - ontological modeling of events and time, - process mining, - modeling of events, states, processes and scenarios in particular domains and interdisciplinary contexts. The workshop has marked the formation of a new sub-discipline in the knowledge engineering, and future effort will be directed to consolidate its conceptual base and transform the existing diversity of approaches to representation of the change into an arsenal of complementary tools sharpened for various spectral regions of tasks in different domains.
The given study is devoted to the issues of searching the ways for adaptation to climate change, mitigation of its impact on the economy and population, as well as to the role of increasing energy efficiency in the economies of some countries of Eastern Europe, Caucasus and Central Asia (EECCA). It also relates to the issues of responding to negative trends and emerging challenges caused by climate change. The Report represents several case studies on the above topics implemented in Moldova, Tadjikistan, Kazakhstan, Azerbaijan and the Russian Federation by the network of regional enviuronmental centres. It also contains consideration of possible methodological approaches and recommendations on addressing the above issues in the EECCA region.
This article attempts to outline the current impact that genetics is having on the fields of archaeology and historical linguistics across the Eurasian continent. It positions the relationship between all three disciplines by reviewing the earlier history of their interactions. In the area of archaeology, there has been a long history of research into the subject of human migration. We briefly review the application of such techniques as craniometry, pigmentation, dermatoglyphics, classical markers and the retrospective reconstruction of population movements from the modern DNA of human populations. We then turn to the revolution created by the application of ancient DNA in three separate areas: Early Man dispersals and legacies, the spread of agriculture and the massive expansion of populations during the Early Bronze Age. Examples are provided of how aDNA is impacting on the study of the origin and dispersals of ethno-linguistic groups. In addition to human migrations, genetics is also impacting on the reconstruction of past lifeways and examples are drawn from research on palaeodiet, palaeopathology and palaeodemography. Genetics is also contributing to major issues of historical linguistics involving the origins and dispersals of the major Eurasian language families. It provides evidence that helps distinguish between instances involving significant migration from those effected by language shift with a minimal genetic trail. Two cases, the Proto-Indo-European and the Proto-Altaic homelands are reviewed along with some of the methodological problems of synchronizing genetic and linguistic evidence.
Single-point mutations in the transmembrane (TM) region of receptor tyrosine kinases (RTKs) can lead to abnormal ligand-independent activation. We use a combination of computational modeling, NMR spectroscopy and cell experiments to analyze in detail the mechanism of how TM domains contribute to the activation of wild-type (WT) PDGFRA and its oncogenic V536E mutant. Using a computational framework, we scan all positions in PDGFRA TM helix for identification of potential functional mutations for the WT and the mutant and reveal the relationship between the receptor activity and TM dimerization via different interfaces. This strategy also allows us design a novel activating mutation in the WT (I537D) and a compensatory mutation in the V536E background eliminating its constitutive activity (S541G). We show both computationally and experimentally that single-point mutations in the TM region reshape the TM dimer ensemble and delineate the structural and dynamic determinants of spontaneous activation of PDGFRA via its TM domain. Our atomistic picture of the coupling between TM dimerization and PDGFRA activation corroborates the data obtained for other RTKs and provides a foundation for developing novel modulators of the pathological activity of PDGFRA.
To address the structural and dynamical consequences of amino-acid attachment at 2′- or 3′-hydroxyls of the terminal ribose in oligoribonucleotides, we have performed an extensive set of molecular dynamics simulations of model aminoacylated RNA trinucleotides. Our simulations suggest that 3′-modified trinucleotides exhibit higher solvent exposure of the aminoacylester bond and may be more susceptible to hydrolysis than their 2′ counterparts. Moreover, we observe an invariant adoption of well-defined collapsed and extended conformations for both stereoisomers. We show that the average conformational preferences of aminoacylated trinucleotides are determined by their nucleotide composition and are fine-tuned by amino-acid attachment. Conversely, solvent exposure of the aminoacylester bond depends on the attachment site, the nature of attached amino acid and the strength of its interactions with the bases. Importantly, aminoacylated CCA trinucleotides display a systematically higher solvent exposure of the aminoacylester bond and a weaker dependence of such exposure on sidechain interactions than other trinucleotides. These features could facilitate hydrolytic release of the amino acid, especially for 3′ attachment, and may have contributed to CCA becoming the universal acceptor triplet in tRNAs. Our results provide novel atomistic details about fundamental aspects of biological translation and furnish clues about its primordial origins.
Article presents reply on re-analysis of Durkee, published as Durkee PK. 2019 Do the Maasai perceive weak walkers to be stronger and more attractive than strong walkers? A re-analysis of Fink et al. (2019). Biol. Lett 15, 20190240. (doi:10.1098/rsbl.2019.0240).
Background: Two recent meta-analyses have suggested the association between digit ratio (2D:4D) and ag-
gression is weak. This conclusion has been criticised because the meta-analyses conflate forms of aggression that show strong sex differences with those that do not, and most studies have considered post-pubertal participants. Aims: We test the influence of 2D:4D and ethnicity in the expression of aggression in children and adolescents in four ethnic groups of European and African origin.
Study design: Buss and Perry aggression questionnaire. Direct measurement of the 2nd and 4th digits. Subjects: 1296 children and adolescents from Tanzania and Russia from 4 ethnic groups – Datoga, Meru, Russians, Tatars. Results: There were ethnic and gender differences in ratings on aggression with boys consistently reporting more physical aggression. In all four samples right 2D:4D was significantly lower in boys, compared to girls. With regard to our total sample of boys, the right 2D:4D was significantly and negatively associated with self-ratings on physical aggression, but no association was found for left 2D:4D. No associations between 2D:4D and physical aggression were found for girls. Hostility was negatively correlated with 2D:4D for boys, and anger was posi- tively correlated with 2D:4D in girls. Conclusion: Sex differences were strongest for right 2D:4D (boys < girls), and for physical aggression (boys > girls). Right 2D:4D was negatively related to physical aggression in boys only, suggesting possible relationship to prenatal androgenization.
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified molecules with high activities against tick-borne encephalitis virus (TBEV). Pentaerythritol-based polyazides were used for the assembly of molecules containing 2/4 antiviral 5-(perylen-3-ylethynyl) uracil scaffolds, the first examples of polyvalent perylene antivirals. Cluster compounds showed enhanced absorbance, however, their fluorescence was reduced due to self-quenching. Due to the solubility issues, Pom group removal succeeded only for compounds with one peryleneethynyluracil unit. Four compounds, including one ramified cluster 9f, showed remarkable 1/3 nM EC50 values against TBEV in cell culture.
Three natural glycosylated macrolide compounds, known irumamycin 1 and X-14952B 2, as well as new isoirumamycin 3, were isolated from ethyl acetate mycelium extract of Streptomyces sp. INA-Ac-5812. Structures of the compounds were elucidated using 1D and 2D NMR. Isoirumamycin 3 was found to be an isomer of irumamycin with an 18-membered macrolactone ring instead of 20-membered macrolide in irumamycin. A previously unknown stereo configuration of irumamycin epoxide (C23, C24) and hemiketal (C3, C7) fragments was deduced from NMR data (ROESY/NOESY and HSQMBC). Cytotoxic, antifungal and antibacterial activities were studied for all isolated compounds. Comparison of the collected data showed crucial importance of 20-membered macrolactone ring for antimicrobial properties of this antibiotic family.
Rigid amphipathic fusion inhibitors (RAFIs) are potent antivirals based on a perylene core linked with a nucleoside moiety. Sugar-free analogues of RAFIs, 5-(perylen-3-ylethynyl)uracil-1-acetic acid 1 and its amides 2, were synthesized using combined protection group strategy. Compounds 1 and 2 appeared to have low toxicity on porcine embryo kidney (PEK) or rhabdomiosarcoma (RD) cells together with remarkable activity against enveloped tick-borne encephalitis virus (TBEV): EC50 values vary from 0.077 mM to subnanomolar range. Surprisingly, 3-pivaloyloxymethyl (Pom) protected precursors 7 and 8 showed even more pronounced activity. All the compounds showed no activity against several nonenveloped enteroviruses, except 4-hydroxybutylamides 2d,g, which inhibited the reproduction of enterovirus A71 with EC50 50e100 mM, with a non-specific mode of action. The results suggest that the carbohydrate moiety of RAFI nucleosides does not play a crucial role in their antiviral action, and biological activity of the 5-(perylen-3-ylethynyl)uracil scaffold can be effectively modulated by substituents in positions 1 and 3. The high antiviral activity of these new compounds, coupled with low toxicity advocate their potential role in antiviral therapy.
The phenoxazine scaffold is widely used to stabilize nucleic acid duplexes, as a part of fluorescent probes for the study of nucleic acid structure, recognition, and metabolism, etc. Here we present the synthesis of phenoxazine-based nucleoside derivatives and their antiviral activity against a panel of structurally diverse viruses: enveloped DNA herpesviruses varicella zoster virus (VZV) and human cytomegalovirus, enveloped RNA tick-borne encephalitis virus (TBEV), and non-enveloped RNA enteroviruses. Studied compounds were effective against DNA and RNA viruses reproduction in cell culture. 3-(2′-Deoxy-β-D-ribofuranosyl)-1,3-diaza-2-oxophenoxazine proved to be a potent inhibitor of VZV replication with superior activity against wild type than thymidine kinase deficient strains (EC50 0.06 and 10 μM, respectively). This compound did not show cytotoxicity on all the studied cell lines. Several compounds showed promising activity against TBEV (EC50 0.35–0.91 μM), but the activity was accompanied by pronounced cytotoxicity. These compounds may be considered as a good starting point for further structure optimization as antiherpesviral or antiflaviviral compounds.