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Антимикробные пептиды, нацеленные на липид II мембран бактерий: ключевой принцип действия
С. 60-60.
In book
Т. 2. , М. : Издательство "Перо", 2019
Panina I., Chugunov A., Krylov N. et al., В кн. : Сборник научных трудов VI съезда биофизиков России. Т. 1.: Краснодар : Полиграфическое объединение «Плехановец», 2019. С. 83-84.
Устойчивость микроорганизмов к применяемым в клинической практике антибиотикам является серьезной проблемой медицины во всем мире. В связи с этим одной из актуальных задач современной фармакологии является поиск или дизайн новых антибактериальных веществ, свободных от бремени резистентности. Перспективными кандидатами для разработки новых лекарств являются антимикробные пептиды (АМП). Среди всего разнообразия АМП особое внимание привлекают пептиды, мишенью ...
Added: November 1, 2019
Степанова Е. В., Штиль А. А., Лавренов С. Н. et al., Russian Chemical Bulletin, Россия 2010 № 12 С. 2203-2211
Tris(1-alkylindol-3-yl)methanes were obtained and oxidized into tris(1-alkylindol-3-yl)methylium salts. The resulting salts are more toxic to cultured tumor cells than to non-tumor ones. The cytotoxicity of tris(1-alkylindol-3-yl)methylium salts depends on the length of the substituent at the N atom of the heterocycle, increasing from an N-unsubstituted derivative toward N-butyl- and N-pentyl derivatives. A further increase in ...
Added: July 14, 2015
Panina I., Chugunov A., Dmitry Nolde et al., , in : FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019. Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford : Wiley, 2019. Ch. 27-069. P. 269-269.
The worldwide rapid emergence of resistant bacteria put at threat the efficacy of antibiotics, thus the development of novel antibacterial agents is urgently needed. The cell wall precursor lipid II consisting the chemically conservative pyrophosphate group represents a promising pharmaceutical target. Antimicrobial peptides, that target lipid II, i.e. lantibiotic nisin, could be excellent prototypes for ...
Added: November 1, 2019
Lohan S., Mandal D., Choi W. et al., Journal of Medicinal Chemistry 2022 Vol. 65 No. 1 P. 665-687
We report the synthesis and antibacterial activities of a series of amphiphilic membrane-active peptides composed, in part, of various non-genetically coded hydrophobic amino acids. Lead cyclic peptides, 8C and 9C, showed broad-spectrum activity against drug-resistant Gram-positive (MIC=1.5-6.2 µg/mL) and Gram-negative (MIC=12.5-25 µg/mL) bacteria. Cytotoxicity study showed the predominant lethal action of the peptides against bacteria ...
Added: February 1, 2022
Bocharov E. V., Lesovoy D. M., Bocharova O. V. et al., Biochimica et Biophysica Acta - General Subjects 2018 Vol. 1862 No. 6 P. 1410-1420
Background: Prior studies of the human growth hormone receptor (GHR) revealed a distinct role of spatial rearrangements of its dimeric transmembrane domain in signal transduction across membrane. Detailed structural information obtained in the present study allowed elucidating the bases of such rearrangement and provided novel insights into receptor functioning.
Methods: We investigated the dimerization of recombinant ...
Added: April 5, 2018
Bershatsky Y., Kuznetsov A., Idiatullina A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 4 Article 3906
Human InsR, IGF1R, and IRR receptor tyrosine kinases (RTK) of the insulin receptor
subfamily play an important role in signaling pathways for a wide range of physiological processes
and are directly associated with many pathologies, including neurodegenerative diseases. The
disulfide-linked dimeric structure of these receptors is unique among RTKs. Sharing high sequence
and structure homology, the receptors differ dramatically ...
Added: May 19, 2023
Dubovskii P., Ignatova A., Feofanov A. et al., Bioorganic and Medicinal Chemistry Letters 2020 Vol. 30 No. 3 P. 126890
Antibacterial activity of the three-finger toxins from cobra venom, including cytotoxin 3 from N. kaouthia,
cardiotoxin-like basic polypeptide A5 from N. naja (CLBP), and alpha-neurotoxin from N. oxiana venom, was
investigated. All toxins failed to influence Gram-negative bacteria. The most pronounced activity against Bacillus
subtilis was demonstrated by CLBP. The latter is ascribed to the presence of additional ...
Added: August 21, 2020
Efremov R., Дубовский П. В., Воронцова О. В. et al., Mendeleev Communications 2015 Vol. 25 No. 1 P. 70-71
The investigation of antibacterial activity of three-finger cobra cytotoxins towards Gram-negative and Gram-positive bacteria showed no activity against the former species, whereas M. luteus was found most susceptible to cytotoxins. A correlation was revealed between this activity and hydrophobicity of the toxins (HTL scores), total charge and its distribution over the toxin molecule: the absence ...
Added: July 21, 2015
В.А. Коршун, Russian Chemical Bulletin 2019 Vol. 68 No. 5 P. 955-966
New biologically active substances isolated from natural sources provide valuable information
on structural motifs that are important for a specifi c type of activity and can also be used
as drugs or serve as raw materials for chemical modifi cation in order to develop new pharmaceuticals.
This review considers natural antibiotics combining two pharmacophores in their
structure: a redox-active ...
Added: November 8, 2019
Polyansky A., Kuznetsov A., Volynsky P. et al., , in : Biomembranes 2018. International Conference. 1-5 October 2018. Book of Abstracts. : Dolgoprudni : MIPT, 2018. P. 89-90.
A computational approach to the analysis of structural and dynamical properties of all components of model membranes - membrane proteins, lipids, water and ions - has been developed. It is established that local changes in the membrane environment play an important role in the binding of membrane-active peptides and peripherical membrane proteins, causing specific clustering ...
Added: October 23, 2018
Kuznetsov A., Efremov R., В кн. : Тезисы докладов XXVI Международной конференции "Математика. Компьютер. Образование". МКО-2019. : [б.и.], 2019. С. 45-45.
Transmembrane (TM) helices are one of the most common structural elements in membrane proteins. Their interaction in lipid environment governs the formation of protein spatial structure formation and functioning in normal and pathology. Receptor tyrosine kinases are a wide class of protein molecules having single helix as their TM domain, so dimerization process is crucial ...
Added: November 1, 2019
Dubovskii P., Efremov R., Expert Review of Proteomics 2018 Vol. 15 No. 11 P. 873-886
Introduction: Being important representatives of various proteomes, membrane-active cationic peptides (CPs) are attractive objects as lead compounds in the design of new antibacterial, anticancer, antifungal, and antiviral molecules. Numerous CPs are found in insect and snake venoms, where many of them reveal cytolytic properties. Due to advances in omics technologies, the number of such peptides ...
Added: October 24, 2018
Chugunov A., Panina I., Nolde Dmitry E. et al., , in : Biomembranes 2018. International Conference. 1-5 October 2018. Book of Abstracts. : Dolgoprudni : MIPT, 2018. P. 105-106.
Antibiotics resistance is a major threat to global health, so development of novel classes of antibiotics is urgently needed. Lantibiotics are natural compounds that effectively control bacterial populations, thus study of the molecular mechanisms of recognition of their targets in bacterial membrane may drive creation of novel antibiotic molecules. Many of them target lipid II ...
Added: October 23, 2018
Omelchuk O., Malyshev V., Medvedev M. et al., Journal of Organic Chemistry 2021 Vol. 86 No. 12 P. 7975-7986
Oligomycin A is a potent antibiotic and antitumor agent. However, its applications are restricted by its high toxicity and low bioavailability. In this study, we obtained Oligomycin A Diels− Alder adducts with benzoquinone and N-benzylmaleimide and determined their absolute configurations by combining 1H and ROESY NMR data with molecular mechanics conformational analysis and quantum chemical ...
Added: September 6, 2021
Vladimir A. Korshun, Frontiers in Microbiology 2018 Vol. 9 P. 868
Endophytic actinobacteria are one of the important pharmaceutical resources and well known for producing different types of bioactive substances. Nevertheless, detection of the novelty, diversity, and bioactivity on endophytic actinobacteria isolated from mangrove plants are scarce. In this study, five different mangrove plants, Avicennia marina, Aegiceras corniculatum, Kandelia obovota, Bruguiera gymnorrhiza, and Thespesia populnea, were collected from Beilun Estuary National Nature ...
Added: November 8, 2019
Ikonnikova V., Solyev P., Terekhov S. et al., ChemistrySelect 2021 Vol. 6 No. 42 P. 11775-11778
A short collective total synthesis of rearranged angucyclinones related to Elmenols A and B was achieved by ortho-lithiation/addition/transacetalisation sequence on the key step. Naphthalene and isocoumarine carbaldehydes required for synthesis were obtained in a straightforward manner by either of suitable methods: 1) palladium-catalyzed formylation, 2) halogen-lithium exchange, 3) decarboxylation of alpha-ketoacid. ...
Added: November 13, 2021
Vladimir A. Korshun, Microorganisms 2018 Vol. 6 P. 52
Whole genome sequencing of actinomycetes has uncovered a new immense realm of microbial chemistry and biology. Most biosynthetic gene clusters present in genomes were found to remain “silent” under standard cultivation conditions. Some small molecules—chemical elicitors—can be used to induce the biosynthesis of antibiotics in actinobacteria and to expand the chemical diversity of secondary metabolites. Here, we outline a ...
Added: November 8, 2019
Alferova V., Shuvalov M., Korshun V. A. et al., Russian Chemical Bulletin 2019 Vol. 68 No. 5 P. 955-966
Added: April 24, 2020
Panina I., Chugunov A., Nolde D. et al., FEBS Open Bio 2021 Vol. 11 No. Suppl.1 P. 356-356
Given the challenge of global antibiotic resistance, the development of new medications is indispensable. Lipid II - bacterial cell wall precursor – is a promising pharmaceutical target for innovative antibiotics, whereas lantibiotic nisin, effectively capturing lipid II’s conservative pyrophosphate group, is a potential prototype of a new generation of antibiotics. Because the structure of membrane-bound ...
Added: August 31, 2021
Gavira J. A., Rico-Jiménez M., Ortega A. et al., mBio 2023 Vol. 14 No. 1 Article e03363-22
Bacteria have evolved a sophisticated array of signal transduction systems that allow them to adapt their physiology and metabolism to changing environmental conditions. Typically, these systems recognize signals through dedicated ligand binding domains (LBDs) to ultimately trigger a diversity of physiological responses. Nonetheless, an increasing number of reports reveal that signal transduction receptors also bind ...
Added: January 27, 2024
Kuznetsov A., Maurice P., Efremov R., , in : FEBS Open Bio Volume 9, Issue S1 Supplement: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019. Vol. 9: 44th FEBS Congress, From Molecules to Living Systems, Krakow, Poland, July 6‐11, 2019.: Oxford : Wiley, 2019. Ch. 27-068. P. 268-269.
Receptor tyrosine kinases (RTK) are vital players in cell signaling governing growth and proliferation. These integral membrane proteins work only in dimeric states, so the conformation of transmembrane dimer determines the signal transferred into cell. Here, we used modern molecular modeling techniques to study details of protein-protein and protein-lipid interactions in model systems containing monomers ...
Added: November 1, 2019
Tharra P., Mikhaylov Andrey A., Švejkar J. et al., Angewandte Chemie - International Edition 2022 Vol. 61 No. 17 Article e202116520
Added: February 17, 2022
Mikhaylov A. A., Ikonnikova V., Solyev P., Natural Product Reports 2021 Vol. 38 P. 1506-1517
The unusual framework of the middle C-ring, “broken” as a result of biotransformations and oxidations in vivo and bearing an sp3-C connection, is of interest for biosynthetic investigations. The reported 39 natural compounds (55 including stereoisomers) have been analyzed and arranged into three structural groups. The biosynthetic origin of all these compounds has been thoroughly reviewed and ...
Added: February 2, 2021
Bocharov E. V., Mineev K. S., Pavlov K. V. et al., Biochimica et Biophysica Acta - Biomembranes 2017 Vol. 1859 No. 4 P. 561-576
Interaction between transmembrane helices often determines biological activity of membrane proteins. Bitopic proteins, a broad subclass of membrane proteins, form dimers containing two membrane-spanning helices. Some aspects of their structure-function relationship cannot be fully understood without considering the protein-lipid interaction, which can determine the protein conformational ensemble. Experimental and computer modeling data concerning transmembrane parts ...
Added: February 15, 2017