"Achilles Heel" of the Bacterial Membranes: Computational Modeling of Lipid II - Target for Novel Antibiotics
Antibiotics resistance is a major threat to global health, so development of novel classes of antibiotics is urgently needed. Lantibiotics are natural compounds that effectively control bacterial populations, thus study of the molecular mechanisms of recognition of their targets in bacterial membrane may drive creation of novel antibiotic molecules. Many of them target lipid II - unique molecule of bacterial membranes that limits synthesis of cell wall. The core of recognition pattern is a pyrophosphate group, which can represent a pharmaceutical target. Here we present the realistic model of lipid II in native environment and establish a pharmacophore of pyrophosphate recognition by nisin molecule.