• A
  • A
  • A
  • ABC
  • ABC
  • ABC
  • А
  • А
  • А
  • А
  • А
Regular version of the site
Of all publications in the section: 583
Sort:
by name
by year
Article
Степанова Е., Штиль А., Лавренов С. и др. Известия РАН. Серия химическая. 2010. № 12. С. 2203-2211.

Tris(1-alkylindol-3-yl)methanes were obtained and oxidized into tris(1-alkylindol-3-yl)methylium salts. The resulting salts are more toxic to cultured tumor cells than to non-tumor ones. The cytotoxicity of tris(1-alkylindol-3-yl)methylium salts depends on the length of the substituent at the N atom of the heterocycle, increasing from an N-unsubstituted derivative toward N-butyl- and N-pentyl derivatives. A further increase in the length of the N-alkyl substituent lowers the cytotoxicity. The cytotoxicity of tris(1-alkylindol-3-yl)methylium salts for tumor cells correlates with their antibacterial and antifungal activity. Tris(1-alkylindol-3-yl)methylium salts produced a cytocide effect on Gram-positive microorganisms and the most active compounds, on Gram-negative microorganisms as well. Similar patterns of the structure-activity relationship of N-alkylated tris(indol-3-yl)methylium derivatives, which was observed for various lines of tumor cells, bacteria, and fungi, suggest the general character of the mechanisms of the death of prokaryotic and eukaryotic cells induced by these compounds.

Added: Jul 14, 2015
Article
Ревич Б. А., Харькова Т. Л., Кваша Е. А. и др. Проблемы прогнозирования. 2014. № 2. С. 127-135.
Added: Mar 21, 2014
Article
Бердышева Е. С. Экономическая социология. 2014. Т. 15. № 5. С. 9-44.

The act of purchase and sale cannot be realized without product quality evaluation and price reasonableness analysis. In this respect, the processes of definition, stabilization and institutionalization of categories, revealing the contents of goods become of key importance in the framework of contemporary markets. This article reconstructs categories which operationalize the content and quality of Moscow dental market health services and reveals the social order effective there. The article non only analyzes the content of commercial clinics marketing efforts directed at qualifications of their services, but the representation of the quality of the different participants in this market (doctors, managers of clinics and patients) as well. Special attention is given to the way the patients evaluate medical services quality while choosing a clinic. Based on the data of clinics’ websites and in-depth interviews with market participants it can be concluded that there is no quality criteria consensus on the studied market. According to respondents with different background the success of a dental treatment depends on the professionalism of the doctor. And the latter is perceived as the motivation towards professional activity highlighting rendering services to patients rather than skill and experience level. As far as doctors are concerned, the quality of dental services requires integrated approach to treatment contributing to general maintaining of a person’s health. However, patients often come to a clinic when dental problems cannot be longer ignored, and they want to solve them quickly, permanently and in line with modern ideas about how healthy teeth should look like. At the same time no matter how much effort the clinic invests into explanation of its competitive advantages, the customers prefer to trust someone from their reference group who had already experienced the quality of dental services with their body and wallet. Although, the investments clinics make into the qualification of quality in the market are not in vain. The patients use their market discourse cognitive categories both when asking details about the clinic from friends and if doubting the reasonableness of the price paid for the treatment. Thus, the dental market conventional lexicon is defined by parameters that comprise dental services and constitute their quality.

Added: Mar 2, 2015
Article
Чащин В. П., Ковшов А., Гудков А. Б. и др. Экология человека. 2016. № 6. С. 3-8.
Added: Oct 17, 2016
Article
Засимова Л. С., Коссова Е. В., Рязанова М. Д. Прикладная эконометрика. 2014. № 34(2). С. 95-119.

The paper discusses factors that have impact on individual attitudes towards bans on smoking in a number of public places — hospitals, universities, work sites, sports facilities, cafes and restaurants, bars and clubs. Using data from national public opinion survey conducted in 2011 by Levada Center for HSE we show that support of smoking bans varies across types of public places and depends on different social and economic characteristics of individuals. Smoking is an important but not the only determining factor.

Added: Aug 5, 2014
Article
Мухин К. Ю., Пылаева О. А., Бородин Р. А. и др. Русский журнал детской неврологии. 2015. Т. X. № 1. С. 4-15.

Research on comparative efficаcy and tolerability of monotherapy with Depakine chronosphere, drugs of Carbamazepine group with ex- tended release and oxcarbazepine in symptomatic and cryptogenic focal epilepsy has been conducted at Svt. Luka’s Institute of Child Neurol- ogy and Epilepsy (ICNE) (Moscow). This retrospective study covers a random sample of patients treated in ICNE in the period from Decem- ber 1, 2013 to September 1, 2014. The study included 131 patients aged 1 to 18 years with symptomatic and cryptogenic focal epilepsy receiving treatment with one of the study drugs in monotherapy: group 1 - monotherapy with Depakine chronosphere (n = 56); group 2 - monotherapy with drugs of carbamazepine group with extended release (n = 55); group 3 - monotherapy with oxcarbazepine (trileptal) (n = 20).The obtained results allow us to conclude that the effectiveness of Depakin chronosphere, carbamazepine with extended release and oxcar- bazepine in monotherapy of symptomatic and cryptogenic focal epilepsy was comparable (statistically significant differences in efficacy were not found). However, carbamazepine was awarded the highest frequency of seizures aggravation.Drugs showed approximately same tolerability (statistically significant differences in tolerability were not found). However, withdrawal of the drug due to side effects was the rarest in Depakine (3.5 %), and withdrawal due to intolerance was higher in carbamazepine and oxcarbazepine (5 and 10 % respectively).Depakinum and oxcarbazepine had the best results in the blocking of pathological activity on the electroencephalogram, whereas carbam- azepine was clearly inferior to them. In this regard, complete clinical-electroencephalographic remission (lasting 12 months or more) was achieved under treatment of Depakine chromosphere in 21.5 % of cases, oxcarbazepine - 20 %, and carbamazepine - only 11 %. Holding on therapy for 12 months was similar in all study drugs.Considering that the objective of epilepsy treatment is to achieve complete control over seizures, or at least substantially reduce and weaken them in the absence of significant side effects that disturb the patient’s quality of life, it can be concluded that the best treatment results were obtained in group of depakine chronosphere therapy.

Added: Oct 14, 2016
Article
Юдина Н., Карачунский А., Румянцева Ю. и др. Вопросы гематологии, онкологии и иммунопатологии в педиатрии. 2015. Т. 14. № 1. С. 16-25.
This paper presents the results of randomized study of the efficacy of two glucocorticosteroids (GCS) in induction therapy of children and adolescents with acute lymphoblastic leukemia (ALL). A total of 1064 primary patients with ALL, aged 1–18 years, were registered from 18.04.2002 to 15.11.2006 in Russia and Belarus Republic. Randomization was carried out before induction therapy. The patients received the dexamethasone (Dexa; 6 mg/m2) “sleeve” of ALL-MB 2002 protocol (n = 539) or the methylprednisolone (MePred; 60 mg/m2) “sleeve” of the protocol (n = 525). The survival rates virtually did not differ: 10-year event-free survival (EFS) was 73 ± 2% in the Dexa group vs. 70 ± 2% in MePred group, p = 0.260; 10-year overall survival (OS) was 79 ± 2 and 77 ± 2%, respectively; p = 0.232; the incidence of relapses after ALL induction therapy by different GCS virtually did not differ. The incidence of isolated central nervous system relapses (1.7% in patients receiving Dexa and 3% in patients treated by MePred; p = 0.138) and of combined relapses with central nervous system involvement differed just negligibly (3.2% in Dexa group and 3.4% in MePred group; p = 0.937). The induction mortality was also similar (3.2% in Dexa group and 3.8% in MePred group; p = 0.677). Retrospective comparison in different age groups showed predominant efficacy of Dexa in children under 14 years of age. This fact deserves further research in prospective randomized multicenter studies.
Added: Oct 18, 2016
Article
Назарова В. В., Леонтьев О. В., Черный В. С. Главный врач: Хозяйство и право. 2015. № 1. С. 18-23.

Income from payment of insurance premiums for compulsory health insurance and shortages on contributions, tax payments and the added penalty fee and penalties, means of the federal budget transferred to the budget of Federal fund regarding compensation of the dropping-out income in connection with establishment of the lowered tariffs of insurance premiums for compulsory health insurance, means of budgets of subjects of the Russian Federation, the income from placement of temporarily available funds, other sources provided by the legislation of the Russian Federation on a plan of authors of the Law has to cover costs of delivery of health care in system of compulsory health insurance. Medical insurance companies have to control quality, volume and validity of medical care, to represent interests of the insured. Medical institutions have to be interested in providing the qualitative help in sufficient volume and carrying out preventive actions.

Added: Feb 24, 2016
Article
Власов В. В. Здравоохранение. 2013. № 3. С. 76-83.

The develoopment of the technical regulation in the Russian medicine in the end 20 ссутегкн and in 21 century was called 'standardization' and included the range of aspects regulated by federal documents, regulating health care and the financing.

Added: Mar 16, 2014
Article
Власов В. В. Здравоохранение. 2013. № 4. С. 70-76.

The develoopment of the technical regulation in the Russian medicine in the end 20 ссутегкн and in 21 century was called 'standardization' and included the range of aspects regulated by federal documents, regulating health care and the financing.

Added: Mar 16, 2014
Article
Иванов М. В. Украинский научно-медицинский молодежный журнал. 2011. № S3. С. 29-30.

Spatial notions among the 4-7 years children with normal and dysontogenetic schizotypical diathesis research results are analyzed in the article. Present research gives an opportunity to diagnose cognitive sphere distortions on the early stages of the psychic pathology (latent forms, risk state).

Added: Nov 5, 2013
Article
Гришунина Ю.Б., Контаров Н., Архарова Г. и др. Эпидемиология и вакцинопрофилактика. 2015. Т. 14. № 5(84). С. 13-21.

A calculation method and a variation method of parameters of the epidemic situation model taking into account external risks is proposed. The detailed step-by-step algorithm available in the application EXCEL for the calculation and analysis of the model parameters based on the results of observations is given. The prognosis of the epidemic situation with the estimation of the disease outbreak duration and the total number of population members involved in the outbreak is constructed. We investigated the epidemic situation by an example of reports of a diseases group acute viral respiratory infections-flu in one of the districts of the Moscow region.

Added: Nov 9, 2015
Article
Михальский А. И., Цурко В. Успехи геронтологии. 2013. Т. 26. № 4. С. 766-774.
Added: Nov 15, 2013
Article
Давыдова О. А., Кислякова М. В., Костылев В. А. и др. Медицинская физика. 2016. № 1(69). С. 70-77.

This article analyses the radiotherapy status in Russia in comparison with the other countries in the world against a background of cancer death rate. The Assessment of the potential of the country or region to render a radiotherapy service is given. In particular, the authors offer the comparison on the number of accelerators and radiotherapy centers in the regions of Russia. The need for equipment, radiation oncologists and medical physicists per number of patients and population is shown. A simplified method of the quantitative assessment of the quality of the technical equipment of radiotherapy centers is presented.

Added: Mar 31, 2016
Article
Власов В. В., Плавинский С. Л. Медицинское образование и профессиональное развитие. 2012. № 1. С. 7-14.

Unfortunately the teaching statistics in the medical school is insufficient. Only the most diligent physicians learn the basics of statistical analysis on theirself or find the possibility to get a special course similar to the summer schhool of the research methods in First state moscow emdical university I. Sechenov

Added: Mar 16, 2014
Article
Александрова Н. В., Школьникова М. А., Длин В. В. и др. Вестник Российской академии медицинских наук. 2016. Т. 71. № 5. С. 397-405.

Background: Analysis of publication activity in the field of biomedicine shows insignificant input of Russia in the world scientific product. This is largely due to the lack of incentives for researchers. Article describes stimulation of researchers in Russia, compares it with foreign models, formulates main shortcomings of support and stimulation of research in Russia and introduces the concept of effective contract. Aims: Development of personnel motivation and stimulation of employees of scientific and research organizations in the field of health. Materials and methods: As a successful experience the article describes the implementation of effective contract in Veltishev Research and Clinical Institute for Pediatrics where for years remuneration of researchers depended upon their positions without consideration of research results. Effective contract brought significant changes in the traditional system setting new performance and efficiency criteria. New evaluation system took into account publication activity, presentation activity, implementation of research results, raising scientific personnel, thesis work and income-generating activities. Results: Introduction of effective contract already in the second year led to a rise in the number of foreign publications, publications in journals with impact factor of more than 2, the general increase in the number of articles in peer-reviewed journals with impact factor more than 0.3, the growth of the number of articles by 1 researcher, Hirsch index improving both by individual employees and the entire Institute, increase of grant activity and presentation activity at top-rated professional congresses. The growth of publication and presentation activities has been achieved at the reduction of research staff by 23%. From financial viewpoint effective contract resulted in the redistribution of resources in favour of more efficient researchers. Conclusions: The introduction of effective contract and increase of requirements for scientific output did not cause resistance of staff, although demanded certain time for joint development of criteria by scientific community, as well as the development and implementation of soft for continuous assessment of research activity

Added: Dec 3, 2016
Article
Рыков Ю. Г., Кольцова Е. Ю., Мейлахс П. А. Социологические исследования. 2016. № 8. С. 30-42.

With the rapid growth of online social network sites (SNS), the issue of health-related online communities and its social and behavioral outcomes has become increasingly popular in Internet studies and sociology of health and medicine. This paper presents the results of the empirical study investigating the structure of the 'friendship' networks and participants' communicative activity within 15 online groups on VK.com SNS. In this pilot study we seek to trace the relation between declared aims (social functions) and structure of online groups devoted to the HIV/AIDS theme. First, we propose a classification of online HIV-related groups according to their declared purposes and actual social functions. The most widespread group types on VK.com SNS are HIV activists, HIV-infected dating groups, AIDS denialists movement groups, online pages of offline organizations and social support groups. Second, we identify and describe several patterns of network structure and user behavior occurring among these groups. We distinguish five types of community structure: tight crowd, polarized crowd, stratified structure, clustered network and disintegrated structure. Finally, we find and interpret the relation between the purposes and functions, on the one hand, and network structure of online communities, on the other. Tight crowd networks mainly occur in dating groups for HIV-infected persons and, and links in them are determined by users' gender (either homogeneous or heterogeneous ties prevail). Stratified structure is related to HIV activists and especially to AIDS denialists movement groups. The crucial factor of network formation for this pattern is participation in public discussion within a group. Active users form a cohesive community while passive users stay isolated or connected with just a few active users. Our findings are consistent with some previous research on communication network structures on other social media platforms.

Added: Apr 11, 2016
Article
Маркова А. А. Экономическая социология. 2010. Т. 11. № 4. С. 137-159.

The author studies relationships between medical representatives and physicians from the structural embeddedness perspective. Based on the research she discloses the existing practices of relationships between pharmaceutical companies and physicians, describes possible ways of resolving administrative and legal problems associated with new regulations of drug turnover. The author also gives attention to the dissolution of ties as an important element of network analysis.

 

Added: Oct 12, 2012
Article
Симаков О. В. ИКС-медиа, Россия. 2017. № 1-2. С. 3-4.
Added: Sep 7, 2017
Article
Сакевич В. И. Демоскоп Weekly. 2016. № 671-672.
Added: Sep 27, 2016