In the internal medicine wide spectrum the gastroenterology is one of the chapters, less enlightened by the scientific evidence. It does not mean that the practice of the grasntroenterology may ot be improved by the systematic use of the approaches of the evidence based medicine
According to a systematic review of published data in both the national and international scientific indexing systems, including the results of our own researches, there have been selected evidence-based criteria and internal genotype-phenotype risk determinants for assessing the individual susceptibility to the acute cold exposure. In accordance with these criteria, the list of cold-related health conditions was defined. This list includes 33 classes and groups of diseases and conditions by ICD-10 codes, arising from or tightly associated with the cold exposure. According to the comorbidity principles, the novel quantitative predictive model for assessing the individual susceptibility to the acute cold exposure was developed and validated. This assessment takes into account, in addition to the meteorological risk factors, also internal risk determinants, including physical status, behavioral, pathogenic and functional disorders, as well as receiving thermoregulation-altering pharmaceuticals prescribed by recommended therapeutic doses. The algorithm for calculating the individual health risk and recommended time limits based on the use of suggested comorbidity index for the acute exposure to cold in an open area or in unheated premises without special active thermal protection is described.
The paper represents an application of agent based approach for simulation modeling as the new way to create epidemic models. It is much differed from common disease spreading simulation technique, which uses differential equations. The AnyLogic 6 agent based computer simulation model of the influenza spreading was created. The model allows making a short-range sickness rate forecast based on current morbidity statistics.
Evidence based medicine (EBM) is a bridge between the science and the medical practice. Today there is a range of terms in use, and there is a discussion on their application. IN this text authors discuss the essense of the EBM, specifically - the process of proving the statement.
Theoretical analysis of the spatial cognition's scientific problem is presented in the article. Historical conditionality of the scientific problem in the psychology and psychiatry is dealt with. Spatial cognition and it's distortions' within the neuro-mental pathology ontogenesis is considered in the article.
The paper presents a brief analysis on the quality of cause-specific mortality statistics at old ages in Russia. Two aspects are in focus: the regional differences in approaches for choosing the underlying cause of death and the comparison of Russian coding practice with the practices of some other European countries. The results obtained indicate that there are certain problems with the quality of cause-of-death coding at old ages in Russia. No unified approach to coding deaths as caused by “Senility” is used at a sub-national level. This leads to the distortion of the regional cause-specific mortality structures. Furthermore for many groups of causes Russian death rates are much lower than those in European countries. This peculiarity is caused by the specificity of Russian cause-of-death coding practice which results in underestimating the mortality from certain causes at old ages.