The paper considers a possibility for an application of innovative competitive positioning for private medical clinics in low price segment - "medical clinics un the field of trade retail" or "supermarkets' clinics", ut also considers specifics of such an application. The authors study the possibility of developing a new format of medical services in the segment of primary health and emergency care. The target audience will be youth and young professionals with low level of income and do not have permanent health care provider. They also have no chronic disearses.
The problem aspects of a ban of treatment of drug addiction by Substitution Therapy are considered in this article. The margin of appreciation in regulation of treatment of drug addiction and approach for constructive dialogue between supporters and opponents of Substitution Therapy are shown in this work.
The role of cortisol (Crt), dehydroepiandrosterone (DHEA) and DHEAsulfate (DHEAS) in stress responses were shown. The fluctuations in concentration of Crt, DHEA and DHEAS depending on age, sex and time of the day in norm and under acute and chronic stress were quoted. The main techniques of assessment of serum, urine and saliva Crt concentrations were discussed. A special attention had been paid to the use of Crt concentration in anthropological and psychological research. Bibliography comprises 181 works.
The article problematizes the relationship between music, nature and culture in the heterogeneous discourse of therapeutic effects of music and in critical theory of music by Adorno. To determine the nature of this relationship, the article refers to conceptual metaphors and ontological intuitions of actor-network theory (ANT). Using ANT, the article articulates the concept of “hybrid discourse” that differs from the related concepts of social semiotics and postcolonial theory. This concept is in lesser degree used to describe a local communicative practices that mixes different languages, sociolects, ethnolects and functional styles of speech, and in higher degree used to describe a discursive constructions revealing the symptoms of hybrid activity on the borders of nature and culture. The article analyses the discursive practices of the New Age movement that invokes music — from theosophy in the late XIX century to modern esoteric-therapeutic narratives. In these discursive practices, we find the significant combination of pseudo-religious reenchantment of the world and its radical nihilistic “demusicalization” (in the terminology of Leo Spitzer). In the hybrid esoteric discourses modern socio-acoustic texture of nature–culture is neutralized in favor of transcendent reality of unhuman. In the Adorno’s critical theory ontological dualities are synthesized into the ideological totality of culture industry. Only in the early vanguard of the Second Viennese School Adorno discovers the ghostly possibility of an exit from culture industry and achieving the true nature of music and non-alienated sociality.
Laminins are a family of extracellular heterotrimeric glycoproteins that are the main structural component of basement membranes (BMs), perform a barrier function, and are important for adhesion, dif- ferentiation, migration, and resistance to apoptosis of various cells, including cancer cells. The review sum- marizes the current knowledge of how laminins produced by cancer and normal cells inf luence the key stages of carcinogenesis. Laminin 332 (LN-332) and LN-111 enhance proliferation of certain cancer cells and increase the tumour growth. LN-111 increases resistance to apoptosis, induces differentiation, and inhibits the epithelial–mesenchymal transition (EMT) of cancer cells. LN-332 is associated with higher adhesion and higher migration potential of cancer cells. LN-411 and LN-421 significantly increase motility of cancer cells. LN-332 and LN-511 facilitate cell–cell adhesion and affect the efficacy of cell–cell interactions. The laminin chains α4 and α5 are important for the development and function of blood and lymphatic vessels. The expres- sion ratio of the α4 and α5 laminin chains defines the BM permeability to leukocytes and, presumably, cancer cells in blood and lymphatic vessels. Interactions between LN-511 and α2-containing laminins enhance self- renewal and survival of circulating cancer stem cells. Moreover, laminins are involved in the formation of premetastatic niches and new colonies. Endogenous expression of the α4 laminin chain stimulates prolifera- tion of individualised circulating cancer cells in vitro and in vivo and facilitates micrometastasis.
The results of mathematical modeling of dental implantation in the area of missing premolars and morals of the upper jaw with atrophy of the aveolar bone are presented in this scientific work. Modeling results are compared with the results of clinical study and determining the stability of dental implants after sinus lift. It is proved that there is no difference in stability of the system implant-bone after sinus lifting with different thickness of the aveolar bone after the osseointegration of implants. The results of mathematical modeling correlate to the results of the treatment and can be used to predict the functioning of the system jaw-implant-prothesis in various clinical situations.
In clinical trials comparing experimental and control treatment the effect of treatment often depends on the range of patient’s characteristics (biomarkers) such as clinical, anthropological, genetic, psychological, social characteristics and others. Personalized medicine aims at finding such dependencies to tailor treatment strategies to a patient. This paper presents an overview of the approaches to data analysis of clinical trials intended for identification of influential biomarkers and subgroups of patients, where experimental and control treatment differ significantly in efficiency.