The role of cortisol (Crt), dehydroepiandrosterone (DHEA) and DHEAsulfate (DHEAS) in stress responses were shown. The fluctuations in concentration of Crt, DHEA and DHEAS depending on age, sex and time of the day in norm and under acute and chronic stress were quoted. The main techniques of assessment of serum, urine and saliva Crt concentrations were discussed. A special attention had been paid to the use of Crt concentration in anthropological and psychological research. Bibliography comprises 181 works.
The article problematizes the relationship between music, nature and culture in the heterogeneous discourse of therapeutic effects of music and in critical theory of music by Adorno. To determine the nature of this relationship, the article refers to conceptual metaphors and ontological intuitions of actor-network theory (ANT). Using ANT, the article articulates the concept of “hybrid discourse” that differs from the related concepts of social semiotics and postcolonial theory. This concept is in lesser degree used to describe a local communicative practices that mixes different languages, sociolects, ethnolects and functional styles of speech, and in higher degree used to describe a discursive constructions revealing the symptoms of hybrid activity on the borders of nature and culture. The article analyses the discursive practices of the New Age movement that invokes music — from theosophy in the late XIX century to modern esoteric-therapeutic narratives. In these discursive practices, we find the significant combination of pseudo-religious reenchantment of the world and its radical nihilistic “demusicalization” (in the terminology of Leo Spitzer). In the hybrid esoteric discourses modern socio-acoustic texture of nature–culture is neutralized in favor of transcendent reality of unhuman. In the Adorno’s critical theory ontological dualities are synthesized into the ideological totality of culture industry. Only in the early vanguard of the Second Viennese School Adorno discovers the ghostly possibility of an exit from culture industry and achieving the true nature of music and non-alienated sociality.
The results of mathematical modeling of dental implantation in the area of missing premolars and morals of the upper jaw with atrophy of the aveolar bone are presented in this scientific work. Modeling results are compared with the results of clinical study and determining the stability of dental implants after sinus lift. It is proved that there is no difference in stability of the system implant-bone after sinus lifting with different thickness of the aveolar bone after the osseointegration of implants. The results of mathematical modeling correlate to the results of the treatment and can be used to predict the functioning of the system jaw-implant-prothesis in various clinical situations.
In clinical trials comparing experimental and control treatment the effect of treatment often depends on the range of patient’s characteristics (biomarkers) such as clinical, anthropological, genetic, psychological, social characteristics and others. Personalized medicine aims at finding such dependencies to tailor treatment strategies to a patient. This paper presents an overview of the approaches to data analysis of clinical trials intended for identification of influential biomarkers and subgroups of patients, where experimental and control treatment differ significantly in efficiency.
The limited resources of health care system, combined with an aging population and an increase of proportion of diseases of involutional origin leads to the need to optimize the algorithms of diagnosis and treatment of these diseases. BPH is a gender-associated, socially significant disease, as it accounts for over 40% of all diseases of men older than 50 years, and this is the reason of the significant economic contributions in the cost structure of the health system. Analysis of the effectiveness of medical care for BPH in Russia conducted by the example of the Voronezh region, has revealed several shortcomings, the key ones are: low detection rate of the disease and as a result high costs associated with the need of additional treatment in advanced cases. To improve the quality of care for patients with BPH a comprehensive program of staged standardized care was developed.
Materials and Methods: urological assistance was provided in three stages. In the first stage the problem of BPH early detection was resolved. In the second – patients underwent standart treatment procedures, including surgery. 7 interdistrict urological centers representing second stage were deployed. On the basis of the regional clinical hospital №1 regional urological center was organized – the third stage, where specialists delivered treatment in severe clinical cases.
Results: As a result of program activities, there was a reduction of the specific economic costs in terms of each patient at 21.68%. Number of patients admitted for acute urinary retention as complications of BPH significantly reduced. Surgical activity of interdistrict urological centers (based on central district hospitals) increased at 76,11%.
Conclusions: All given facts show high clinical and economic efficiency of comprehensive staged standardized program of care for patients with BPH, based on the principles of early diagnosis and timely treatment.
Effectiveness of health care can be significantly enhanced through the rational use of its resources. One of the tools to achieve this goal is to use the basic principles of corporate management.
Prospects of modernization and innovative development of the Russian health care on the basis of realization of the opportunities given by information society are discussed. The essence and genesis of information-communication medical-industrial space (ICMIS) are studied. The problem of creation of the information-analytical internet portal of the Russian medical-industrial complex (MIC) is formulated. The methodology of creation of an intellectual control system of innovative development of MIC on the basis of the MIC internet portal is stated.