Analysis of results of epidemiological BOLERO study showed that 2/3 of men with uncontrolled arterial hypertension noted problems in sexual life. Severity of problems in this sphere of life of men correlated positively with age, as well as with presence of difficulties at work, increased fatigability, impossibility to be involved in favorite activity (hobby), disturbances of nocturnal sleep (as assessed by GQLI questionnaire). As a result of 8 weeks therapy which included indapamide retard number of patients noting substantial influence of sexual problems on their habitual way of life (CQLI score >3) decreased almost 2 times (from 25 to 13%, p<0,001). At least 1 point decrease in evaluation of importance of such problems occurred in 33% of cases, 63% of patients did not change their score. An increase of GQLI score was noted in 4% of cases. Multifactorial analysis allowed to reveal that restoration of sexual function went parallel with improvement of quality of life related to recovery of psychosocial relationships and augmentation of physical activity. Moreover it was established that adequate lowering of arterial pressure in men during use of indapamide retard decreased risk of worsening of their sexual function.
The paper suggest that learned helplessness, as a special case of the Pavlovian conditioning, may be accompanied by negative implicit attitudes towards Monday and expectations for Friday as a means to get rid of a «punishment», which may be a factor in the development of emotional exhaustion—a key manifestation of the burnout syndrome
50% patients with chronic disease shows unintentional and intentional medication non-adherence. Medication non-adherence causes 4 to 10% of preventable healthcare losses. SMS reminders are associated with significant improvement in adherence rates. The current paper tests whether the question-behavior effect (QBE) could improve SMS reminders effectiveness. Preliminary RCT (N=40) shows positive, but not significant effect of QBE/SMS combination on medication adherence rates (ASD=0.249 (95% C. I. -0.061 – 0.560)), which corresponds to the predicted effect size (ASD=0.166 (95% C. I. 0.044 – 0.276)). Additional research is required for confirmation of QBE/SMS combination effectiveness.
The article describes the experience of integration of basic principles of corporate management into administration of public hospital.
The results of microwave influence aimed at the temperature rise in local area in multilayered biological tissues are given. the experimental results of temperature distribution in multilayered biological tissue are presented at the electromagnetic field frequency of 2450MHz. The model and analytic calculations for the temperature distribution inside the biological tissue are presented. The calculation results for the temperature distribution in multilayered biological tissues are given.
The hypoxic response critically depends on the rapid stabilization of the Hypoxia-Inducible Factor (HIF). In normoxic conditions, HIF-prolyl hydroxylases mark α-subunits of HIF for degradation, while the hypoxia results in stabilization of HIF-α. Oxyquinoline derivatives suppress the activity of HIF-prolyl hydroxylases, leading to the stabilization of HIF. Here we show that the 24 hour incubation of the trophoblast model choriocarcinoma cells BeWo b30 line with the oxyquinoline derivative leads to a decrease in the transepithelial electrical resistance (TEER) of the cell monolayer, while the permeability of the monolayer for the FITC-dextran (70 kDa) remains unchanged. These observations indicate that the overall barrier function remain preserved, while the structure of intercellular tight junctions may undergo remodeling. Using Affymetrix Human Transcriptome Array 2.0, we show that the treatment with oxyquinoline derivative lead to a decrease in the expression of claudines 6 and 7 (CLDN6, CLDN7), occludin (OCLN), contact adhesion molecule 3 (JAM3) and angiotomin-like protein 1 (AMOTL1), which possibly explain the observed changes in TEER.
The article contains qualitative and quantitative assessment of ART effectiveness on the basis of the data from one Moscow ART clinic, as well as studying patient communities in the Internet.
ART helps to resolve infertility problem to up to 50% of all infertile couples in the world, Europe being a leader in what concerns ART usage/
In the article, there have been presented the results of assessment of working conditions' impact on workers of a vessel metal hulls assembly shop of a machine building plant on levels of morbidity with temporal disability (MTD). The assessment of the working conditions has been made according to the results of the assessment of workplaces, the levels of MTD on the ground of the longterm average annual indices for 2005-2014. The cause-and-effect relations between the working conditions and the MTD levels have been established by means of a comparison of the working conditions' classes according to the results of the workplaces' assessment and the MTD levels characterizing the impact of harmful factors on the most vulnerable human body organs and systems. According to the study results, it has been established that the MTD levels of the respiratory viral infections, diseases of the respiratory organs, diseases of the locomotor system and connective tissue, diseases of the genitourinary system were statistically significantly connected with the effect of low air temperatures, high concentrations of harmful chemical substances in the working zone air, high levels of local vibration and high labor burden.