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Regular version of the site

Article

Активность-зависимая ТМС – совмещение пространственной и временной информации

Новиков П. А., Назарова М. А., Решетников М. Л., Козлова К. Д., Макарова М. М., Никулин В. В.

Transcranial magnetic stimulation (TMS) is a powerful tool for non-invasive brain modulation and investigation in normal and pathological conditions. One of the most serious problems limiting the TMS use is the high variability of its effects. In recent years, it became widely accepted that the effect of the TMS protocol is not a property of the protocol itself, but a consequence of the interactions of TMS with the neuronal system trait and state. Thus, it is necessary to develop TMS approaches that take into account the ongoing neuronal activity, the so-called state/activity-dependent TMS. This paper presents software that allows considering both the position of the stimulator and the ongoing neuronal activity for TMS triggering. Automatic TMS initiation was demonstrated when all the conditions were met (the beginning of the movement execution, lack of the unnecessary preactivation, the proper coil position). The delay for TMS triggering was tested in an experiment with stimulation triggered by the onset of the desired movement. The development of such technical solution for neuronavigated activity-dependent TMS is important to bring TMS methodology to a new level of its individualized application.