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Comparative analysis of esterase and paraoxonase activities of different serum albumin species
Journal of Evolutionary Biochemistry and Physiology. 2017. Vol. 53. No. 4. P. 271-281.
Goncharov N., Terpilovskii M. A., Shmurak V., Belinskaya D., Avdonin P.
Enzymatic activities of three types of serum albumin—rat, bovine and human—were analyzed comparatively using a mathematical model. Kinetic and equilibrium constants of carboxylesterase and paraoxonase activities of albumin in Sudlow’s sites I and II were determined. The effects of specific ligands, ibuprofen and warfarin, on enzyme kinetics in these sites were studied. Ibuprofen was found to have an inhibitory effect both on carboxylesterase and paraoxonase albumin activities, whereas warfarin specifically inhibited only carboxylesterase albumin activity.
Goncharov N., Belinskaia D., Shmurak V. et al., Molecules 2017 Vol. 22 No. 7 P. 1-27
The albumin molecule, in contrast to many other plasma proteins, is not covered with a carbohydrate moiety and can bind and transport various molecules of endogenous and exogenous origin. The enzymatic activity of albumin, the existence of which many scientists perceive skeptically, is much less studied. In toxicology, understanding the mechanistic interactions of organophosphates with ...
Added: June 25, 2019
Покровский В. С., Чернов Н. Н., Ryskina H., М. : Е-ното, 2020
Представленные в пособии тестовые вопросы могут служить для проверки и углубления знаний по биологической химии при подготовке к рубежному контролю и экзамену. В сборнике содержится 2930 тестовых заданий, сгруппированных в 40 разделов, соответствующих темам учебника "Биологическая химия" под авторством Т.Т. Берёзова, Б.Ф. Коровкина, а также учебного пособия "Основы биохимии" под редакцией Н.Н. Чернова и B.C. ...
Added: February 14, 2021
Lukashina N., Kartysheva E., Spjuth O. et al., Journal of Cheminformatics 2022 Vol. 14 Article 49
Polypharmacy refers to the administration of multiple drugs on a daily basis. It has demonstrated effectiveness in treating many complex diseases , but it has a higher risk of adverse drug reactions. Hence, the prediction of polypharmacy side effects is an essential step in drug testing, especially for new drugs. This paper shows that the ...
Added: October 11, 2022
Vladimir A. Korshun, Prokhorenko I., Tyurin A. et al., MedChemComm 2018 Vol. 9 No. 4 P. 667-675
The study of an archived sample of crystallomycin complex using HPLC, ESI HRMS, and 2D NMR showed
that two major components of the antibiotic, compounds 1 and 2, are lipopeptides having the same peptide
core, Asp1-cycloIJDab2-Pip3-MeAsp4-Asp5-Gly6-Asp7-Gly8-Dab9-Val10-Pro11-), N-acylated either
with Δ3-iso-tetradecenoyl or Δ3-anteiso-pentadecenoyl that are identical to aspartocins C and B, respectively.
According to the 2D NMR study, compound 2 ...
Added: November 8, 2019
Krasavin M., Lukin A., Sukhanov I. et al., Biomolecules 2022 Vol. 12 No. 11 Article 1650
A focused in-house library of about 1000 compounds comprising various heterocyclic motifs in combination with structural fragments similar to β-phenethylamine (PEA) or tyramine was screened for the agonistic activity towards trace amine-associated receptor 1 (TAAR1). The screening yielded two closely related hits displaying EC50 values in the upper submicromolar range. Extensive analog synthesis and testing ...
Added: February 8, 2024
Долгопрудный : МФТИ, 2021
Труды 63-й Всероссийской научной конференции МФТИ. Включены результаты оригинальных исследований студентов, аспирантов, преподавателей и научных сотрудников МФТИ и дружественных учебных и научных организаций. Статьи представляют интерес для специалистов, работающих в области радиотехники и компьютерных технологий ...
Added: October 29, 2021
Krivovicheva V., Bubyrev A., Kalinin S. et al., ChemMedChem 2023 Vol. 18 No. 10 Article e202200607
A newly introduced diazo reagent, 1-diazo-N,N-bis(4-methoxybenzyl)methanesulfonamide, enables access to a range of azole-based primary sulfonamides via [3+2] cycloaddition followed by protecting group removal. Such compounds are representative of the sulfonamide chemical space highly relevant but hitherto not investigated in the context of inhibition of therapeutically relevant isoforms of carbonic anhydrase enzyme. Using this reagent, three ...
Added: January 26, 2024
В. А. Коршун, Prokhorenko I., Биоорганическая химия 2017 Т. 43 № 4 С. 377-387
The synthesis of phosphoramidite reagents and solid-phase supports for the preparation of oligonucleotides
labeled on various locations within the oligonucleotide chain (including multiple modification) with biotin,
lipoic acid, amino group and terminal acetylene, is described. The efficiency of the reagents and solid supports
is confirmed by the synthesis of corresponding modified oligonucleotides. ...
Added: November 6, 2019
Olloqui-Sariego J. L., Zakharova G., Poloznikov A. et al., Electrochimica Acta 2020 Vol. 351 P. 136465
A major challenge in the design of electrochemical biodevices is to achieve fast rates of electron exchange between proteins and electrodes. In this work, we show that a significant increase in the direct electron transfer rate between a graphite electrode and Tobacco Peroxidase takes place when a surface exposed leucine, located in the vicinity of ...
Added: July 22, 2020
Gevorgiz R. G., M. A. Gureev, Zheleznova S. N. et al., Applied Biochemistry and Microbiology 2022 Vol. 58 No. 3 P. 261-268
The production of diadinoxanthin and its cytostatic activity in an intensive culture of C. closterium has been estimated via molecular modeling and experiments with the human tumor cell cultures OVCAR5, OVCAR8, KURAMOCHI, and OVSAHO. According to data from both the simulation and experiments with the cell cultures, diadinoxanthin demonstrates lower activity (by more than four times) in ...
Added: February 8, 2024
М. : Энциклопедия, Инфра-М, 2017
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 31, 2018
Автономная некоммерческая организация «Национальный научно-образовательный центр «Большая российская энциклопедия» (АНО БРЭ), 2022
Основными задачами Портала являются создание и поддержание в актуальном состоянии электронной национальной базы знаний на русском языке, консолидирующей сведения об окружающем мире, предназначенной для широкого круга пользователей, а также популяризация науки, трансфер научных результатов в образование, культура использования данных и научные междисциплинарные коммуникации. Важнейшая социальная функция Портала — доступность правдивой научной информации и формирование доверия пользователя к ней.
Контент портала
Основу контента составляют дополненные и расширенные статьи «Большой ...
Added: September 12, 2022
М. : Энциклопедия, Инфра-М, 2018
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 28, 2018
Lohan S., Konshina A. G., Efremov R. et al., Journal of Medicinal Chemistry 2023 Vol. 66 No. 1 P. 855-874
A series of small (7- to 12-mer) amphipathic cationic peptides were designed and synthesized with the ultimate goal of creating a set of short helical peptides with broad-range bactericidal activity and good selectivity toward the bacterial cells. Activity analysis identified a lead 12-mer peptide 8b with broad spectrum activity against Gram-positive (MIC=3.1-6.2 µg/mL) and Gram-negative ...
Added: February 21, 2023
Babich O., Larina V., Krol O. et al., Pharmaceutics 2023 Vol. 15 No. 2 Article 616
Tanacetum vulgare is an herbaceous plant widely used in folk medicine. It is rich in phenolic acids and flavonoids, which have pharmacological and medicinal properties, such as anthelmintic, antispasmodic, tonic, antidiabetic, diuretic, and antihypertensive. This study aimed to confirm the presence of biologically active substances in Tanacetum vulgare and to determine the pharmacological spectrum of ...
Added: February 1, 2024
Galenko E., Galenko A., Novikov M. et al., ChemistrySelect 2017 Vol. 2 No. 25 P. 7508-7513
New β‐diazopyrrole and β‐triazenylpyrrole derivatives were synthesized from isoxazoles and pyridinium salts in two and three steps, respectively. The apoptotic/necrotic difference for these compounds was estimated on THP‐1 cell line. The most effective of the panel is methyl 3‐diazo‐2‐(2,4‐dimethylphenyl)‐4‐phenyl‐3H‐pyrrole‐5‐carboxylate which demonstrated cytotoxic activity from the lowest concentration of 3.3 μM with a steep rise of the ...
Added: June 25, 2019
Rogacheva E., Kraeva L., Lukin A. et al., Molecules 2023 Vol. 28 No. 18 Article 6491
A series of eight 5-nitrofuran-tagged oxazolyl tetrahydropyrazolopyridines (THPPs) has been prepared in six stages with excellent regioselectivity. The testing of these compounds against pathogens of the ESKAPE panel showed a good activity of lead compound 1-(2-methoxyethyl)-5-(5-nitro-2-furoyl)-3-(1,3-oxazol-5-yl)-4,5,6,7-tetrahydro-1H-pyrazolo[4,3-c] pyridine (13g), which is superior to nitrofurantoin. These results confirmed the benefit of combining a THPP scaffold with a ...
Added: January 26, 2024
Derkach K., Maxim A. Gureev, Babushkina A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 5 Article 4498
Dual inhibitors of protein phosphotyrosine phosphatase 1B (PTP1B)/T-cell protein phosphotyrosine phosphatase (TC-PTP) based on the 3-(hydroxymethyl)-4-oxo-1,4-dihydrocinnoline scaffold have been identified. Their dual affinity to both enzymes has been thoroughly corroborated by in silico modeling experiments. The compounds have been profiled in vivo for their effects on body weight and food intake in obese rats. Likewise, ...
Added: February 1, 2024
Springer, 2019
This unique work compiles the latest knowledge around veterinary nutraceuticals, commonly referred to as dietary supplements, from ingredients to final products in a single source. More than sixty chapters organized in seven sections collate all related aspects of nutraceutical research in animal health and disease, among them many novel topics: common nutraceutical ingredients (Section-I), prebiotics, ...
Added: June 25, 2019
Panina I., Balandin S., Tsarev A. et al., International Journal of Molecular Sciences 2023 Vol. 24 No. 2 P. 1
To date, a number of lantibiotics have been shown to use lipid II — a highly conserved peptidoglycan precursor in the cytoplasmic membrane of bacteria — as their molecular target. The α-component (Lchα) of the two-component lantibiotic lichenicidin (Lchα), previously isolated from the Bacillus licheniformis VK21 strain, seems to contain two putative lipid II binding ...
Added: February 21, 2023
Vladimir A. Korshun, RSC advances 2019 Vol. 9 No. 45 P. 26014-26023
The propargylamide of N3-Pom-protected 5-(perylen-3-ylethynyl)uracil acetic acid, a universal precursor, was used in a CuAAC click reaction for the synthesis of several derivatives, including three ramified molecules with high activities against tick-borne encephalitis virus (TBEV). Pentaerythritol-based polyazides were used for the assembly of molecules containing 2/4 antiviral 5-(perylen-3-ylethynyl) uracil scaffolds, the first examples of polyvalent perylene antivirals. Cluster compounds ...
Added: November 8, 2019
М. : Энциклопедия, Инфра-М, 2017
The New Russian Encyclopedia is a fundamental reference publication in 18 volumes that characterizes nature, population, economy, history, science, art, technology and other important aspects. Contains about 60,000 articles, about 30,000 biographies, about 15,000 color illustrations, maps, charts, diagrams, tables. Leaves since 2003. ...
Added: October 29, 2018
Sapegin A., Rogacheva E., Kraeva L. et al., Biomedicines 2022 Vol. 10 No. 9 Article 2203
A chemically diverse set of 13 5-nitrofuran-tagged heterocyclic compounds has been prepared via the Groebke–Blackburn–Bienaymé multicomponent reaction. The testing of these compounds against the so-called ESKAPE panel of pathogens identified an apparent lead compound—N-cyclohexyl-2-(5-nitrofuran-2-yl)imidazo[1,2-a]pyridine-3-amine (4a)—which showed an excellent profile against Enterobacter cloacae, Staphylococcus aureus, Klebsiella pneumoniae, and Enterococcus faecalis (MIC 0.25, 0.06, 0.25 and 0.25 µg/mL, respectively). Its antibacterial ...
Added: February 8, 2024
Vlasova K. Y., Vishwasrao H., Abakumov M. A. et al., Scientific Reports 2020 Vol. 10 P. 4745
Remote nano-magneto-mechanical actuation of magnetic nanoparticles (MNPs) by non-heating extremely low frequency magnetic field (ELF MF) is explored as a tool for non-invasive modification of bionanomaterials in pharmaceutical and medical applications. Here we study the effects of ELF MF (30-160 Hz, 8-120 kA/m) on the activity and release of a model enzyme, superoxide dismutase 1 (SOD1) immobilized ...
Added: May 12, 2020