Objective — to make a systematic search and an analysis of evidence for the long-term population-based efficiency of screenings and other measures implemented in the framework of Stage 1 screening during periodical health check in the Russian Federation according to the Order №36ан dated 2015. Material and methods. A systematic search was carried out independently by two authors in four databases: Scientific Electronic Library, Cochrane Library, Medline/PubMed, and USPSTF. Systematic reviews are an investigated publications type. The criteria for the efficacy of screening were overall and specific mortality and disability. The methodological quality of systematic reviews was assessed by two authors by the procedure using the international AMSTAR questionnaire. Results. Only a fecal occult blood test and abdominal aorta ultrasonography have a scientific justification as screening methods in certain age and gender populations by the criterion for reducing the specific mortality, while the methodological quality of systematic reviews is high and medium/high. The efficiency of mammography in women has not been proven in high methodological quality studies.