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Spike Frequency Adaptation
Scholarpedia. 2014. Vol. 9. No. 2. P. 30643.
Zeldenrust F., Гуткин Б. С.
When stimulated with a square pulse or step, many neurons show a reduction in the firing frequency of their spike response following an initial increase (Fig. Figure 1 B). This phenomenon is called spike-frequency adaptation. In this article several cellular mechanisms leading to spike-frequency adaptation and its consequences will be discussed.
Language:
English
Keywords: computational neuroscience
Publication based on the results of:
Krupa M., Gielen S., Гуткин Б. С., Journal of Computational Neuroscience 2014 Vol. 37 No. 2 P. 357-376
Gamma oscillations are a prominent phenomenon related to a number of brain functions. Data show that individual pyramidal neurons can fire at rate below gamma with the population showing clear gamma oscillations and synchrony. In one kind of idealized model of such weak gamma, pyramidal neurons fire in clusters. Here we provide a theory for ...
Added: December 22, 2014
Sorokin K., Зайцев А. В., Левин А. М. et al., / Cornell University. Series arxiv:q-bio.NC "arxiv Quantitative Biology". 2023.
In the present study we have used a set of methods and metrics to build a graph of relative neural connections in a hippocampus of a rodent. A set of graphs was built on top of time-sequenced data and analyzed in terms of dynamics of a connection genesis. The analysis has shown that during the ...
Added: October 5, 2023
Adaptation and inhibition control pathological synchronization in a model of focal epileptic seizure
Buchin A., Kerr C. C., Huberfeld G. et al., eNeuro 2018 Vol. 0019-18 P. 1-14
Pharmacoresistant epilepsy is a common neurological disorder in which increased neuronal intrinsic excitability and synaptic excitation lead to pathologically synchronous behavior in the brain. In the majority of experimental and theoretical epilepsy models, epilepsy is associated with reduced inhibition in the pathological neural circuits, yet effects of intrinsic excitability are usually not explicitly analyzed. Here ...
Added: December 20, 2018
Keramati M., Гуткин Б. С., Plos One 2013 Vol. 8 No. 4
Despite explicitly wanting to quit, long-term addicts find themselves powerless to resist drugs, despite knowing that drug-taking may be a harmful course of action. Such inconsistency between the explicit knowledge of negative consequences and the compulsive behavioral patterns represents a cognitive/behavioral conflict that is a central characteristic of addiction. Neurobiologically, differential cue-induced activity in distinct ...
Added: March 10, 2015
Dipoppa M., Гуткин Б. С., Front Comput Neurosci 2013 Vol. 7 No. 139
Working memory (WM) requires selective information gating, active information maintenance, and rapid active updating. Hence performing a WM task needs rapid and controlled transitions between neural persistent activity and the resting state. We propose that changes in correlations in neural activity provides a mechanism for the required WM operations. As a proof of principle, we ...
Added: December 22, 2014
Flexible frequency control of cortical oscillations enables computations required for working memory
Dipoppa M., Гуткин Б. С., Proceedings of the National Academy of Sciences of the United States of America 2013 Vol. 110 No. 31 P. 12828-33
Cognitive effort leads to a seeming cacophony of brain oscillations. For example, during tasks engaging working memory (WM), specific oscillatory frequency bands modulate in space and time. Despite ample data correlating such modulation to task performance, a mechanistic explanation remains elusive. We propose that flexible control of neural oscillations provides a unified mechanism for the ...
Added: December 23, 2014
Morozova E., Faure P., Гуткин Б. С. et al., eNeuro 2020 Vol. 7 No. 4 P. 1-13
The addictive component of tobacco, nicotine, acts via nicotinic acetylcholine receptors (nAChRs). The β2 subunit-containing nAChRs (β2-nAChRs) play a crucial role in the rewarding properties of nicotine and are particularly densely expressed in the mesolimbic dopamine (DA) system. Specifically, nAChRs directly and indirectly affect DA neurons in the ventral tegmental area (VTA). The understanding of ...
Added: September 9, 2020
Pospelov N., Chertkov A., Beketov M. et al., / Cornell University. Series arxiv:cs.NE "arxiv Neural and Evolutionary Computing". 2023.
Neural networks (NNs), both living and artificial, work due to being complex systems of neurons, each having its own specialization. Revealing these specializations is important for understanding NNs inner working mechanisms. The only way to do this for a living system, the neural response of which to a stimulus is not a known (let alone ...
Added: January 24, 2024
Novikov N., Гуткин Б. С., Physical Review E - Statistical, Nonlinear, and Soft Matter Physics 2020 Vol. 101 No. 5 P. 052408
Information storage and processing in the brain largely relies on the neural population coding principle. In this framework, information is reflected in the population firing rate that reflects asynchronous irregular spiking of its constituent neurons. Periodic modulations of neural activity can lead to neural activity oscillations. Data indicate that such oscillations are ubiquitous in brain ...
Added: September 9, 2020
Fontolan L., Krupa M., Hyafil A. et al., Journal of Mathematical Neuroscience 2013 Vol. 3 No. 1
In this paper, we study the dynamics of a quadratic integrate-and-fire neuron, spiking in the gamma (30-100 Hz) range, coupled to a delta/theta frequency (1-8 Hz) neural oscillator. Using analytical and semianalytical methods, we were able to derive characteristic spiking times for the system in two distinct regimes (depending on parameter values): one regime where the gamma ...
Added: December 29, 2014
Graupner M., Maex R., Гуткин Б. С., PLoS Computational Biology 2013 Vol. 9 No. 8
Nicotine exerts its reinforcing action by stimulating nicotinic acetylcholine receptors (nAChRs) and boosting dopamine (DA) output from the ventral tegmental area (VTA). Recent data have led to a debate about the principal pathway of nicotine action: direct stimulation of the DAergic cells through nAChR activation, or disinhibition mediated through desensitization of nAChRs on GABAergic interneurons. ...
Added: December 23, 2014
Гуткин Б. С., di Volo M., Morozova E. et al., European Journal of Neuroscience 2019 Vol. 50 P. 2282-2296
A large body of data has identified numerous molecular targets through which ethanol (EtOH) acts on brain circuits. Yet how these multiple mechanisms interact to result in dysregulated dopamine (DA) release under the influence of alcohol in vivo remains unclear. In this manuscript, we delineate potential circuit‐level mechanisms responsible for EtOH‐dependent dysregulation of DA release from ...
Added: October 27, 2018
Cazé R. D., Humphries M., Гуткин Б. С., PLoS Computational Biology 2013 Vol. 9 No. 2
Local supra-linear summation of excitatory inputs occurring in pyramidal cell dendrites, the so-called dendritic spikes, results in independent spiking dendritic sub-units, which turn pyramidal neurons into two-layer neural networks capable of computing linearly non-separable functions, such as the exclusive OR. Other neuron classes, such as interneurons, may possess only a few independent dendritic sub-units, or ...
Added: March 10, 2015
Keramati M., Гуткин Б. С., / Cold Spring Harbor Laboratory. Series 005140 "Biorxiv". 2014.
Efficient regulation of internal homeostasis and defending it against perturbations requires complex behavioral strategies. However, the computational principles mediating brain's homeostatic regulation of reward and associative learning remain undefined. Here we use a definition of primary rewards, as outcomes fulfilling physiological needs, to build a normative theory showing how learning motivated behavior is modulated by ...
Added: December 29, 2014