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Найдено 3 208 публикаций
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Статья
Tonevitsky A. G., Maltseva D. V., Abbasi A. et al. BMC Physiology. 2013. Vol. 13.

Background

MiRNAs are essential mediators of many biological processes. The aim of this study was to investigate the dynamics of miRNA-mRNA regulatory networks during exercise and the subsequent recovery period.

Results

Here we monitored the transcriptome changes using microarray analysis of the whole blood of eight highly trained athletes before and after 30 min of moderate exercise followed by 30 min and 60 min of recovery period. We combined expression profiling and bioinformatics and analysed metabolic pathways enriched with differentially expressed mRNAs and mRNAs which are known to be validated targets of differentially expressed miRNAs. Finally we revealed four dynamically regulated networks comprising differentially expressed miRNAs and their known target mRNAs with anti-correlated expression profiles over time. The data suggest that hsa-miR-21-5p regulated TGFBR3, PDGFD and PPM1L mRNAs. Hsa-miR-24-2-5p was likely to be responsible for MYC andKCNJ2 genes and hsa-miR-27a-5p for ST3GAL6. The targets of hsa-miR-181a-5p included ROPN1L and SLC37A3. All these mRNAs are involved in processes highly relevant to exercise response, including immune function, apoptosis, membrane traffic of proteins and transcription regulation.

Conclusions

We have identified metabolic pathways involved in response to exercise and revealed four miRNA-mRNA networks dynamically regulated following exercise. This work is the first study to monitor miRNAs and mRNAs in parallel into the recovery period. The results provide a novel insight into the regulatory role of miRNAs in stress adaptation.

Добавлено: 30 октября 2015
Статья
Grinkrug E. M. International Journal of Software Engineering & Applications. 2014. Vol. 5. No. 4. P. 83-101.

This paper presents an approach to dynamic component composition that facilitates creating new composed components using existing ones at runtime and without any code generation. The dynamic abilities are supported by extended type notion and implementation based on additional superstructure provided with its Java API and corresponding JavaBeans components. The new component composition is performed by building the composed prototype object that can be dynamically transformed into the new instantiable type (component). That approach demonstrates interrelations between prototype-based and class-based component-oriented programming. The component model proposed can be used when implementing user-defined types in declarative languages for event-driven applications programming.

Добавлено: 2 сентября 2014
Статья
Колотев С. В., Малютин А. А., Burovski E. et al. Physica A: Statistical Mechanics and its Applications. 2018. Vol. 499. P. 142-147.
Добавлено: 4 февраля 2018
Статья
Anton Kocheturov, Mikhail Batsyn, Panos M. Pardalos. Physica A: Statistical Mechanics and its Applications. 2014. Vol. 413. P. 523-533.
Добавлено: 24 июля 2014
Статья
Shapoval S., Le Mouël J., Shnirman M. et al. JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. 2017. Vol. 122. No. 12. P. 11,874-11,887.
Добавлено: 30 января 2018
Статья
Daryin A., Korzh A. Supercomputing Frontiers and Innovations. 2014. Vol. 1. No. 3. P. 56-69.

We assess the problem of choosing optimal direct topology for InfiniBand networks in terms of performance. Newest topologies like Dragonfly, Flattened butterfly and Slim Fly are considered, as well as standard Tori and Hypercubes.We consider some reasonable extensions to InfiniBand hardware which could be implemented by vendors easily and may allow reasonable routing algorithms for such topologies. A number of routing algorithms are proposed and compared for various traffic patterns. Mapping algorithms for Dragonfly and Flattened Butterfly are proposed. Based on this research it has been decided to use Flattened Butterfly topology for system #22 in November 2014 Top 500 list.

Добавлено: 27 марта 2015
Статья
Panasyuk M. I., Zhukova E. I., Kalegaev V. V. et al. JOURNAL OF GEOPHYSICAL RESEARCH-SPACE PHYSICS. 2021. Vol. 126. No. 3.
Добавлено: 25 марта 2021
Статья
Ovchinnikov A., Pogudin G., Scanlon T. Journal of the European Mathematical Society. 2019.
Добавлено: 1 ноября 2019
Статья
Artemov A. Lobachevskii Journal of Mathematics. 2018. Vol. 39. No. 3. P. 309-320.
Добавлено: 7 сентября 2018
Статья
Obolenskaya L., Zaporozhets M., Kuzmicheva G. et al. Crystallography reports. 2015. Vol. 60. No. 3. P. 406-417.

The structural and morphological features of samples containing titanium dioxide, obtained by the sulfate method in the presence of methylene blue dye MeB (sample with η-TiO2) and in its absence (sample with anatase), have been determined using a complex of analytical methods. For the sample with η-TiO2, the sizes of titanium dioxide crystallites (5.0(2) nm) are smaller than the nanoparticle sizes (5.5–9.0 nm), which does not exclude their defect structure. This sample exhibited a higher tendency of nanoparticles to agglomeration (the presence of strong bonds between nanoparticles) and a low tendency to aggregation (the presence of weak bonds). It is shown that a MeB-modified sample with η-TiO2 has high photocatalytic activity in the visible spectral range in the model reaction of methyl orange dye decomposition. © 2015, Pleiades Publishing, Inc.

Добавлено: 7 сентября 2015
Статья
Korotkov A., Kazakov A., Леванова Т. А. European Physical Journal: Special Topics. 2019. Vol. 228. No. 10. P. 2325-2337.
Добавлено: 18 октября 2019
Статья
Sergei Valentinovich Fedorenko. IEEE Access. 2021. Vol. 9. P. 38673-38686.
Добавлено: 15 апреля 2021
Статья
Vyalyi M., Cheng Q., Tarasov S. Theory of Computing Systems. 2010. Vol. 46. P. 120-142.
Добавлено: 17 октября 2014
Статья
Grines V., Malyshev D., Pochinka O. et al. Regular and Chaotic Dynamics. 2016. Vol. 21. No. 2. P. 189-203.
Добавлено: 5 апреля 2016
Статья
Malyshev D., Pardalos P. M. Doklady Mathematics. 2014. Vol. 89. No. 2. P. 253-256.
Добавлено: 18 апреля 2014
Статья
Goldengorin B. I., Malyshev D., Pardalos P. M. Doklady Mathematics. 2013. Vol. 87. No. 3. P. 368-371.

The notion of a tolerance of an element of a combinatorial optimization problem is often used for stability analysis of an optimal solution and it is a base for design branch-and-bound algorithms solving such problems. In this paper we show that for the weighted independent set problem on trees with n vertices all upper and lower tolerances related to this solution can be computed with O(n) time.

Добавлено: 23 июня 2013
Статья
Savchenko A. PeerJ Computer Science. 2019. Vol. 5:e197. P. 1-26.
Добавлено: 12 июня 2019
Статья
Kogan K., Nikolenko S. I., Eugster P. et al. IEEE Transactions on Networking. 2017. Vol. 25. No. 6. P. 3309-3322.
Добавлено: 14 марта 2018
Статья
Dygin D., Grebnev S.V. Математические вопросы криптографии. 2013. Vol. 4. No. 2. P. 47-57.

Предложен подход к эффективной реализации Российского национального стандарта цифровой подписи ГОСТ Р 34.10 в связи с его новыми модификациями. Используются современные алгоритмы скалярного умножения и различные представления эллиптических кривых над простыми полями. Приводятся результаты вычислительных экспериментов и рекомендации по выбору параметров описанных алгоритмов.

Добавлено: 16 декабря 2014
Статья
Gribanov D., Malyshev D., Mokeev D. B. Journal of Applied and Industrial Mathematics. 2020. Vol. 14. P. 480-489.
Добавлено: 30 октября 2020
Статья
Razvenskaya O., Malyshev D. Journal of Applied and Industrial Mathematics. 2021. Vol. 15. No. 1. P. 97-117.
Добавлено: 23 апреля 2021